Sunil Parikh, MD, MPH

Associate Professor of Epidemiology (Microbial Diseases) and of Medicine (Infectious Diseases)

Research Departments & Organizations

School of Public Health: Center for Interdisciplinary Research on AIDS | Epidemiology of Microbial Diseases | YSPH Global Health Concentration

Internal Medicine: Infectious Diseases

Yale Institute for Global Health

MacMillan Center: African Studies

Office of Cooperative Research

Research Interests

Africa; Burkina Faso; Cameroon; Developing Countries; Diagnosis; Epidemiology; Global Health; Infectious Disease Medicine; Malaria; Parasitic Diseases; Public Health; Uganda

Research Summary

Dr. Parikh focuses upon several aspects of malaria in sub-Saharan Africa, including studies focused on optimizing treatment regimens, novel chemoprevention strategies, drug resistance emergence and spread, and parasite dynamics. Current projects include: (1) understanding host factors affecting response to artemisinin-based antimalarial therapies using a combination of individual and population-based pharmacologic approaches to inform treatment guidelines (Uganda); 2) novel use of a chemopreventive measure to reduce malaria (Burkina Faso); and 3) characterizing the epidemiology of non-falciparum species in sub-Saharan Africa (Cameroon). Dr. Parikh has ongoing projects in several African countries, which span observational, interventional, and cross-sectional designs.

Specialized Terms: Translation research in malaria; Pharmacology of antimalarials; HIV-malaria co-infection; Host response to malaria infection; Innate immunity to malaria

Extensive Research Description

1) Antimalarial Therapy in the context of pregnancy, growth/development, and HIV co-infection in Uganda

Major Goal: To assess the pharmacokinetics and pharmacodynamics of artemisinin-combination therapies and their impact upon efficacy and drug resistance in vulnerable populations. We are conducting a randomized controlled trial of two different antimalarial regimens in children with and without HIV in Uganda.

2) Use of novel approaches to preventing malaria in Burkina Faso

Major Goal: We are conducting a cluster-randomized trial of a novel chemopreventive approach in Burkina Faso

3) Studying parasite dynamics and the emergence and spread of drug resistance in parasites in Burkina  Faso

4) Characterizing the epidemiology of non-falciparum species in Cameroon and Uganda.

Activities

  • Malaria research in Cameroon Douala, Cameroon (2017)

  • Viviendas Leon Leon, Nicaragua (2011)

    Board Member, Community development non-profit working in Nicaragua

  • Alliance for Stroke Awareness and Prevention Project New Delhi, India; Kampala, Uganda (2011)

    Board Member, Non-profit working in Uganda and India on projects related to stroke prevention, such as hypertension screening.

  • Malaria Research Burkina Faso (2006)

    Translational research on host response and susceptibility to malaria

  • Malaria research Uganda (2002)

    Translational research in antimalarial therapy and epidemiology

Selected Publications

See list of PubMed publications

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Coauthors

Fangyong Li

Contact Info

Sunil Parikh, MD, MPH
Lab Location
60 College Street, Ste 7th floor
New Haven, CT 06510
Office Location
60 College Street, Ste 724
New Haven, CT 06510
Mailing Address
Epidemiology of Microbial Diseases60 College Street
P.O. Box 208322

New Haven, CA 06520

Parikh Lab