Stephanie Thorn, MSc, PhD

Research Scientist

Research Departments & Organizations

Cardiovascular Medicine: Yale Translational Research Imaging Center (Y-TRIC)

Research Interests

Computed Tomography Angiography; Diseases; Heart Failure; Heart Failure, Diastolic; Hypertrophy, Right Ventricular; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Positron Emission Tomography Computed Tomography; Radionuclide Imaging; Single Photon Emission Computed Tomography Computed Tomography

Research Summary

Dr Thorn’s research has focused on imaging strategies to assess the role of cardiac metabolism, blood flow, and upregulation of angiogenesis and matrix metalloproteinases in cardiac remodeling. Additionally, Dr Thorn is developing quantitative methods for right ventricular blood flow.  Quantitative evaluation of the right ventricle is an emerging methodology due to new developments in nuclear technology.  The ability to interrogate the molecular signaling, perfusion and functional capacity of the right ventricle with non-invasive imaging is of clinical importance in development of therapeutics and risk stratification in patients. 

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Contact Info

Stephanie Thorn, MSc, PhD
Mailing Address
Yale School of MedicinePO Box 208017
DANA 3

New Haven, Connecticut 06520-8017

YTRIC

Right Ventricle Heart Failure

Contrast CT images of a normal myocardium and one with right ventricle heart failure.

Cardiac Ischemia-Reperfusion

Using non-invasive SPECT/CT hybrid imaging, the reduced perfusion area can be quantified. At 3-days post-ischemia, the same area shows an increase in the radiotracer uptake of the matrix metalloproteinase agent, Tc-99m RP805. This tracer is an index of cardiac remodeling.