Stephanie O'Malley, PhD

Professor of Psychiatry; Director, Division of Substance Abuse Research in Psychiatry; Deputy Chair, Clinical Research

Research Departments & Organizations

Psychiatry: ADVANCE Study | Call it a Night | Center for Nicotine and Tobacco Use Research at Yale (CENTURY) | Center for the Translational Neuroscience of Alcoholism | Connecticut Mental Health Center: Division of Substance Abuse | Division of Addictions | Division of Women's Behavioral Health Research | Neuroscience Research Training Program (NRTP) | Psychology Section | Psychotherapy Development Center | Smoking Cessation and Alcohol Treatment Research Clinic | Stress & Addiction Clinical Research Program | Substance Abuse Research | Yale Tobacco Center of Regulatory Science

Yale Cancer Center: Cancer Prevention and Control

Office of Cooperative Research

Research Interests

Alcoholism; Psychiatry; Psychiatry and Psychology; Risk Reduction Behavior; Smoking; Substance-Related Disorders

Research Summary

The goal of our laboratory is to develop more efficacious treatments for alcohol use disorders and nicotine dependence and to provide the science base for the regulation of tobacco products. Toward this end, we are conducting clinical trials to determine efficacy of medications and behavioral interventions, and laboratory studies to determine the mechanisms underlying the effects of treatment and the underlying nature of the disorder. Research on how flavors, such as methol and sweeteners, influence the use of tobacco products is underway to inform the regulation of tobacco products by the FDA.

Specialized Terms: Medications development for alcoholism and smoking; Risk reduction and young adult drinking; tobacco regulatory science; treatment methodology; patient treatment matching; biomarkers of treatment response

Extensive Research Description

Yale Tobacco Center for Regulatory Science

Clinical trials of varenicline for the treatment of alcohol dependence among smokers and of naltrexone for young adult heavy drinkers

Laboratory studies to evaluate medications for substance use disorders

Validation of biomarkers for monitoring drinking in clinical trials

Secondary analyses to identify moderators and predictors of response to treatments for alcohol dependence using tree based and trajectory analyses

Training of clinician and transdisciplinary scientists

Clinical Trials

Conditions Study Title
Alcohol Addiction Sleep Intervention for Heavy Drinking Young Adults
Mental Health & Behavioral Research Mavoglurant in Alcohol Drinking
Addictive Behaviors, Alcohol Addiction, Mental Health & Behavioral Research Saracatinib and Alcohol Drinking
Addictive Behaviors, Alcohol Addiction, Mental Health & Behavioral Research Efficacy and Mechanisms of CBT4CBT for Alcohol Use Disorders
Lung Personalized Prevention: Smoking Cessation in Patients With a Lung Nodule

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Contact Info

Stephanie O'Malley, PhD
Mailing Address
PsychiatryConnecticut Mental Health Center - SAC 202
34 Park Street

New Haven, CT 06508