Research Departments & Organizations
Reproductive Neurosciences Group
My research focuses on CNS (hypothalamic) mechanisms relating to the regulation of energy and glucose homeostasis. These studies on hypothalamic inter- and intra-cellular mechanisms that regulates metabolism add critical information to the current understanding of the central regulation of energy and glucose homeostasis and how alterations in stored energy are sensed in the hypothalamus. The results of my research have important implications for understanding the pathogenesis of metabolic syndrome, obesity and type 2 diabetes, disorders that are the leading cause of morbidity and mortality in the U.S., and the developed world in general, with the highest financial burden on the national economy.
DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons.
Santoro A, Campolo M, Liu C, Sesaki H, Meli R, Liu ZW, Kim JD, Diano S. DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons. Cell Metabolism 2017, 25:647-660. 2017
POMC Neurons: From Birth to Death.
Toda C, Santoro A, Kim JD, Diano S. POMC Neurons: From Birth to Death. Annual Review Of Physiology 2017, 79:209-236. 2017
UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness.
Toda C, Kim JD, Impellizzeri D, Cuzzocrea S, Liu ZW, Diano S. UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness. Cell 2016, 164:872-83. 2016
Hypothalamic POMC neurons promote cannabinoid-induced feeding.
Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, Gao XB, Diano S, Horvath TL. Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature 2015, 519:45-50. 2015