Ronald Duman, PhD

Elizabeth Mears and House Jameson Professor of Psychiatry and Professor of Neuroscience; Director, Abraham Ribicoff Research Facilities

Research Departments & Organizations

Psychiatry: Connecticut Mental Health Center | Division of Molecular Psychiatry | Neuroscience Research Training Program (NRTP) | Stress & Addiction Clinical Research Program | VA National Center for PTSD | VA-Yale Clinical Neurosciences PTSD Research Program

Interdepartmental Neuroscience Program

WHRY Pilot Project Program Investigators

Office of Cooperative Research

Research Interests

Antidepressive Agents; Depression; Gene Expression; Molecular Biology; Neurobiology; Psychiatry; Signal Transduction; Stress, Psychological

Research Summary

Studies in Dr. Duman's laboratory are focused on identifying the molecular and cellular adaptations that underlie the actions of antidepressant drugs and stress. This includes adaptations of receptors, signal transduction proteins, gene transcription factors, neurotrophic factors, and regulation of synaptic processes and even birth of new neurons (neurogenesis) in the adult brain. Preclinical and clinical studies support the hypothesis that neuronal atrophy and cell loss in response to stress contribute to mood disorders. Conversely, the therapeutic action of antidepressants may occur in part via blocking or reversing these damaging effects of stress. A variety of molecular approaches combined with cellular and behavioral studies are conducted to elucidate the basis of complex behavioral abnormalities.

Specialized Terms: Depression; Antidepressants; Stress; Molecular biology; Neuropharmacology Signal transduction pathways; Gene expression; Identifying the molecular and cellular adaptations that underlie the actions of psychotropic drugs and stress

Clinical Trials

Conditions Study Title
Diseases of the Nervous System, Genetics - Adult, Genetics - Pediatric, Mental Health & Behavioral Research Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)

Activities

  • Molecular Mechanisms of Stress & Antidepressants Japan (2008)

    Ronald Duman is collaborating with a number of Japanese researchers to study the molecular and cellular mechanisms underlying the actions of stress and antidepressants.

  • Neurotrophic Factors and Antidepressants India (2008)

    Professor Duman collaborates with a former student on the emphasis on the influence of early postnatal stress and the long-term effects of such stress on the adult animal. This focuses on interests in antidepressants and identifying mechanisms for developing better therapeutic agents. One of the...

Selected Publications

See list of PubMed publications

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