Robert M. Weiss, MD, FACS, FAAP

Donald Guthrie Professor of Urology; Director, Pediatric Urology

Research Departments & Organizations

Urology

Yale Cancer Center: Signal Transduction

Office of Cooperative Research

General Adult Urology

Research Interests

Pharmacology; Signal Transduction; Urinary Bladder Neoplasms; Urology

Research Summary

We are involved in using nano-particle delivery systems to diagnose and treat diseases of the urinary system with special emphasis on benign and malignant diseases of the bladder. These studies, which are presently focused on diagnosing and treating bladder and prostate cancer utilizing nano-particles loaded with specifically targeted siRNAs are directed by Darryl T. Martin, PhD. In addition we are studying the pharmacology and physiology on ureteral-vesical smooth muscle.

Specialized Terms: muscle pharmacology; Signal transduction; Bladder cancer; Drug delivery

Extensive Research Description

The Proof of Concept that we are testing is that intravesical instillation of small interference RNA (siRNA) packaged in biodegradable nanospheres provides wide opportunities for the treatment of urologic diseases including transitional cell carcinoma of the bladder (TCC), interstitial cystitis (IC), overactive bladder, and detrusor hyperreflexia.

Because of their robust, gene selective silencing of target protein expression, siRNA oligonucleotides are an attractive therapeutic option with high selectivity and specificity and minimal toxicity to neighboring cells. siRNAs, however, have a relatively short half-life and thus we are addressing the stabilization and intravesical delivery of siRNAs. To achieve this goal, we plan to create and test clinically viable, non-viral nanosphere siRNA complexes that are intravesically
instilled for treatment of diseases of the urinary tract.

We plan to develop and test a number of nanoparticle controlled release systems containing targeting proteins that will stabilize and deliver siRNAs and drugs and initially test these on bladder cancers

Using nanospheres that contain siRNAs to survivin in combination with chemotherapeutic agents to affect growth and spread of bladder cancer in in vitro and in vivo animal models

Use of nanoparticles for localization and treatment of prostatic carcinoma in a in vivo animal model.

Clinical Trials

Conditions Study Title
Children's Health, Diseases of the Kidney & Urinary Tract OnabotulinumtoxinA for the Treatment of Urinary Incontinence Due to Overactive Bladder in Pediatric Patients

Activities

  • Invited Speaker Avalon, United States (2014 - 2014)

  • Invited Speaker Litchfield, United States (2009 - 2009)

  • Speaker Seattle, United States (2008 - 2008)

  • Invited Speaker San Francisco, United States (2008 - 2008)

  • Invited Speaker Providence, United States (2007 - 2007)

  • Visiting Professor New York, United States (2006 - 2006)

  • Lecturer Amelia Island, United States (2004 - 2004)

  • Invited Speaker Tokyo, Japan (2004 - 2004)

  • Invited Speaker Chicago, United States (2003 - 2003)

  • Visiting Professor Detroit, United States (2002 - 2002)

  • Visiting Professor Chicago, United States (2002 - 2002)

  • Visiting Professor Yonago, Japan (2001 - 2001)

  • Visiting Professor Kumamoto, Japan (2001 - 2001)

  • Visiting Professor New York, United States (2001 - 2001)

  • Invited Speaker New Haven, United States (2001 - 2001)

  • Visiting Professor Norfolk, United States (2000 - 2000)

  • Invited Speaker San Francisco, United States (1998 - 1998)

  • Invited Speaker Boston, United States (1996 - 1996)

  • Visiting Professor Milwaukee, United States (1995 - 1995)

  • Visiting Professor Wilmington, United States (1995 - 1995)

  • Visiting Professor Philadelphia, United States (1995 - 1995)

  • Faculty Houston, United States (1995 - 1995)

  • Visiting Professor Brooklyn, United States (1994 - 1994)

  • Invited Guest Speaker Arkansas, United States (1994 - 1994)

  • Visiting Professor Arkansas, United States (1994 - 1994)

  • Visiting Professor Providence, United States (1993 - 1993)

  • Visiting Professor Tucson, United States (1993 - 1993)

  • Invited Guest Speaker Montreal, Quebec, Canada (1993 - 1993)

  • Invited Speaker New York, United States (1993 - 1993)

  • Guest Lecturer Tokyo, Japan (1992 - 1992)

  • Guest Lecturer Kanagawa, Japan (1992 - 1992)

  • Visiting Professor Tokushima, Japan (1992 - 1992)

  • Guest Lecturer Yonago, Japan (1992 - 1992)

  • Guest Speaker Seoul, South Korea (1991 - 1991)

  • Guest Speaker Williamsburg, United States (1991 - 1991)

  • Guest Lecturer Tokyo, Japan (1991 - 1991)

  • Guest Lecturer Yonago, Japan (1991 - 1991)

  • Guest Lecturer Akita, Japan (1991 - 1991)

  • Guest Lecturer New York, United States (1990 - 1990)

  • Invited Speaker Burlington, United States (1990 - 1990)

  • Presentation New York, United States (1989 - 1989)

  • Presentation Columbus, United States (1989 - 1989)

  • Guest Speaker Stratton Mt., United States (1987 - 1987)

  • State of the Art Lecture Anaheim, United States (1987 - 1987)

  • Visiting Professor Toronto, Canada (1987 - 1987)

  • Lecturer New York, United States (1987 - 1987)

  • Visiting Professor Pusan, South Korea (1985 - 1985)

  • Visiting Professor Seoul, South Korea (1985 - 1985)

  • Guest Lecturer Pusan, South Korea (1985 - 1985)

  • Guest Lecturer Chungju-si, South Korea (1985 - 1985)

  • Visiting Professor Changsa, Hunan, China (1985 - 1985)

  • Guest Lecturer Tokyo, Japan (1985 - 1985)

  • Visiting Professor Akita, Japan (1985 - 1985)

  • Presentation Tokyo, Japan (1985 - 1985)

  • Visiting Professor Norwalk, United States (1984 - 1984)

  • Presentation New York, United States (1983 - 1983)

  • Presentation Chicago, United States (1983 - 1983)

  • Visiting Professor New York, United States (1982 - 1982)

  • Presentation Boston, United States (1982 - 1982)

  • Presentation Kansas City, United States (1982 - 1982)

  • Visiting Professor Padova, Italy (1981 - 1981)

  • Presentation Trieste, Italy (1981 - 1981)

  • Presentation Boston, United States (1981 - 1981)

  • Presentation New York, United States (1980 - 1980)

  • Presentation Boston, United States (1979 - 1979)

  • Presentation Boston, United States (1979 - 1979)

  • Presentation New York, United States (1979 - 1979)

  • Presentation Fuggi Terme, Italy (1978 - 1978)

  • Presentation Chicago, United States (1977 - 1977)

  • Presentation Honolulu, United States (1977 - 1977)

  • Presentation New Haven, United States (1977 - 1977)

  • "Recent Advances in Advancing the Undescended Testis" Boston, United States (1977 - 1977)

  • Presentation Houston, United States (1977 - 1977)

  • Presentation Los Angeles, United States (1974 - 1974)

  • Presentation New Haven, United States (1972 - 1972)

  • Presentation New Haven, United States (1971 - 1971)

  • Presentation Chicago, United States (1969 - 1969)

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Contact Info

Robert M. Weiss, MD, FACS, FAAP
Mailing Address
UrologyPO Box 208058
New Haven, CT 06520-8058

Curriculum Vitae