Robert Roth, Jr, PhD

Professor of Psychiatry

Research Departments & Organizations

Psychiatry: Neural Transplant and Neurobehavior Program

Office of Cooperative Research

Research Interests

Behavior and Behavior Mechanisms; Central Nervous System Diseases; Mental Disorders; Parkinson Disease; Phenomena and Processes; Psychiatry and Psychology

Research Summary

Our laboratory takes a neurochemical approach towards examining neurotransmitter function and the mechanism of action of psychotropic drugs. The major research investigates the biochemical organization, regulatory control, pharmacology, and function of catecholamine-containing neurons in the CNS. We also investigate the post-translational mechanisms by which neuronal impulse flow regulates tyrosine hydroxylase and examine the function of dopamine autoreceptors. Our focus recently has been on central dopamine systems and, in particular, on the mesocortical system. These studies, carried out both in rodents and non-human primates, have revealed that the mesotelencephalic dopamine systems are quite heterogeneous, exhibiting distinct physiological and pharmacological properties. Neural grafting is another research interest of our lab. We are currently investigating the function of neural grafts and stem cells in the MPTP primate model of Parkinson’s disease.

Activities

  • Biomedical Research Saint Kitts and Nevis (1982)

    Biomedical research at a primate research facility that supports a broad range of neuroscience and medical studies that uniquely require the use of nonhuman primates.

Selected Publications

See list of PubMed publications

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