Renato Polimanti, PhD, MSc

Assistant Professor

Research Departments & Organizations

Division of Human Genetics

Research Interests

Biological Psychiatry; Gene-Environment Interaction; Genetic Predisposition to Disease; Genetic Research; Genetics; Genetics, Behavioral; Genetics, Medical; Genetics, Population; Genome-Wide Association Study; Mendelian Randomization Analysis

Research Summary

My primary research focus is to investigate the predisposition to psychiatric disorders, behavioral traits, and other complex traits using genomic data. The ongoing studies are funded by the the American Foundation for Suicide Prevention, the Simons Foundation Autism Research Initiative, the Pfizer ASPIRE Program, and the National Institute on Drug Abuse. 

Extensive Research Description

Dissecting The Genetic Basis of Human-Microbial Oral Interactome in The Context of  Smoking and Drinking Behaviors. The goal is to reveal presently unknown interactions between host and oral microbiome in the context of smoking and drinking behaviors.

Genome-wide investigation of suicide behaviors in the context of substance dependence. The main goal is to gain new insights into the pathophysiology of suicide behaviors in subjects with substance use disorders (SUDs), by increasing our understanding of the underlying genetic basis of suicide.

Cognitive and Brain Imaging Study of Autism Spectrum Disorder Risk Alleles Under Positive Selection in Affected and Unaffected individuals. The main goals are to uncover new insights about the pathophysiology of autism spectrum disorder (ASD), and increase our understanding of the underpinnings of this disorder in the context of human evolution.

Epigenome-wide investigation of medical history in TTR Val122Ile African American carriers. This project investigates the interactions between genetic and epigenetic variation with respect to the phenotypic expression observed among African-American carriers of the Transthyretin Val122Ile mutation.

Investigating the systems genetics of the patterns of polysubstance abuse and addiction. The aim of this project is to conduct a genome-wide analysis of polysubstance use patterns and investigate the results with respect to longitudinal data and epigenetic information.

Selected Publications

See list of PubMed publications

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Contact Info

Renato Polimanti, PhD, MSc

Curriculum Vitae