Research Departments & Organizations
Therapeutic Radiology: Radiobiology
Extensive Research Description
My research is focused on the development of novel cell-based assays for high-throughput screening using genetic and small molecule approaches, both for the creation of novel therapeutics and for new pathway discovery. In addition, I am interested in the development of synthetic lethal targeting strategies for the treatment of tumors with unique genetic aberrations. Clinically, I am focused on the treatment of adult and pediatric CNS tumors. I am interested in leveraging my translational research and clinical experience as a physician-scientist to conduct future investigator-initiated Phase I trials at Yale, based on the results of the drug and genomics screening efforts in my laboratory. I recently completed my residency in radiation oncology at Memorial Sloan-Kettering Cancer Center (MSKCC), and I joined the faculty in the Department of Therapeutic Radiology at Yale in the summer of 2012. I was given the opportunity to pursue a brief period of protected research during residency at MSKCC, which I completed in July 2012. This research time was supported by the Leonard B. Holman Pathway fellowship program. During this time, I developed a high-throughput assay for DNA repair inhibitors, which was published in Nucleic Acids Research. We subsequently utilized this assay in a high-throughput screen for novel DNA repair inhibitors, which identified several novel glioma radiosensitizers. A manuscript from my independent laboratory describing the results was recently published in Molecular Cancer Therapeutics. Our laboratory also recently developed a novel, next-generation sequencing-based assay to measure DNA repair at endogenous loci, which was recently published in DNA Repair. Finally, I recently translated a drug from this screen directly into a Phase I clinical trial for recurrent adult glioma patients. I am the PI of this trial, NCT02202993, which opened for enrollment in August 2014. This work, coupled with my research and publications during my PhD, have equipped me with the necessary skills and experience to begin a career as an independent investigator pursuing highly translational projects.