Ralitza Gueorguieva, PhD

Senior Research Scientist in Biostatistics; Director of Biostatistics in Psychiatry

Research Departments & Organizations

School of Public Health


Center for the Translational Neuroscience of Alcoholism

Neuroscience Research Training Program (NRTP)

Yale Tobacco Center of Regulatory Science

Research Interests

Models, Statistical; Psychiatry; Research Design; Risk Assessment

Research Summary

Professor Gueorguieva's interests are in development and application of statistical methods for the analysis of data from clinical trials and epidemiological studies. She is working on models for repeatedly measured observations, survival outcomes and risk assessment. Her main collaborations are in the area of psychiatry and clinical neuroscience.

Extensive Research Description

Dr. Gueorguieva's research interests are in methodological development of models for longitudinal data and outcomes of different types, assessment of risk and the application of innovative statistical approaches for the analyses of clinical trials data. She has developed statistical techniques for simultaneous analysis of repeatedly measured categorical and continuous outcomes, and of longitudinal and survival outcomes, has developed risk assessment screening algorithms, and has applied trajectory-based approaches and recursive partitioning methods to the assessment of treatment effects. Dr. Gueorguieva is collaborating extensively with psychiatric researchers on clinical trials and observational studies in alcoholism, substance abuse, depression and anxiety disorders, women's behavioral health, schizophrenia, bipolar disorder, obsessive-compulsive disorder and posttraumatic stress disorder. She advocates the use of modern statistical methods such as mixed and mixture models, tree-based methods and nonparametric alternatives to address the complexity of psychiatric data.

  • Predictors and Moderators of Response to Treatment
  • Growth Mixture Modeling of Longitudinal Data
  • Joint Analysis of Repeatedly Measured Outcomes and Competing Risks
  • Center for the Translational Neuroscience of Alcoholism
  • Yale Tobacco Center of Regulatory Science
  • Yale SPORE in Lung Cancer
  • The STRONG STAR Consortium to Alleviate PTSD

Clinical Trials

Conditions Study Title
Addictive Behaviors, Alcohol Addiction, Mental Health & Behavioral Research Behavioral and Neurochemical Mechanisms Underlying Stress-Precipitated Drinking
Lung Personalized Prevention: Smoking Cessation in Patients With a Lung Nodule
Mental Health & Behavioral Research STEP-ED: Reducing Duration of Untreated Psychosis and Its Impact in the U.S.
Addictive Behaviors, Mental Health & Behavioral Research, Tobacco Addiction Flavors and E-cigarette Effects in Adolescent Smokers


  • Teaching Biostatistics to Students Sofia, Bulgaria (2013 - 2013)

    Dr. Gueorguieva taught a course in biostatistics for participants in the M.Sc. program in Probability Theory and Mathematical Statistics and provided mentorship to students at Sofia University.

  • Family Association Study of Neurocognitive Impairment in Patients with Bipolar Disorder Sofia, Bulgaria (2009 - 2009)

    Dr. Gueorguieva provided statistical consultations to the project team.

  • UNICEF Early Child Development Project Bulgaria (2008 - 2008)

    Dr. Gueorguieva provided guidance on statistical analyses to the national team of the Child Nutrition, Rearing and Parenting Practices study in Bulgaria.

  • Research and Teaching Sofia, Bulgaria (2008)

    As an affiliated member of the Section of Probability Theory and Mathematical Statistics, Dr. Gueorguieva has taught training courses, participated in seminars and research projects with Bulgarian scientists.

Selected Publications

See list of PubMed publications

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Contact Info

Ralitza Gueorguieva, PhD
Office Location
60 College Street, Ste 215B
New Haven, CT 06510
Mailing Address
BiostatisticsPO Box 208034
60 College Street

New Haven, CT 06520-8034

Curriculum Vitae