Research Departments & Organizations
Blood-Brain Barrier; Brain; Brain Chemistry; Brain Diseases, Metabolic; Cognition; Diabetes Complications; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Hypoglycemia; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Metabolism; Metabolomics; Nuclear Magnetic Resonance, Biomolecular; Proteomics
Dr. Raimund Herzog is an Assistant Professor in Endocrinology at Yale School of Medicine. He received his M.D. from University of Ulm, Germany before moving to the US, where he pursued his training in Internal Medicine at Yale School of Medicine. He earned his M.H.S. in the YCCI Junior Faculty Scholars program while further specializing in Endocrinology at Yale. In addition to caring for patients at the Yale Diabetes Center and teaching medical students Dr. Herzog maintains an active translational research program. A physician scientist with a strong interest in neuroscience and diabetes Dr. Herzog’s laboratory is focused on characterizing and preventing its central nervous complications. He uses state-of-the-art technologies like in vivo NMR spectroscopy and phospho-proteomics to define the impact of diabetes and intensive insulin treatment on brain metabolism and cognition. His work extends from cell culture and animal models all the way to translation of findings to human subjects with diabetes. It has produced novel insights into the molecular mechanisms underlying brain energy substrate metabolism thereby laying the basis for the development of targeted therapies that will protect the brain from diabetes complications and injury.
In a related area Dr. Herzog’s workgroup has engaged in several collaborative projects that apply his understanding of metabolism towards more comprehensive and unbiased metabolomic analysis of peripheral plasma metabolites in an obese and diabetic adolescent cohort. Furthermore he is exploring the role of circulating small molecules and lipids in the context of aging-related cognitive decline in a cohort of elderly subjects. As part of these studies he has established a close working relationship with the Keck Mass Spectrometry Center and the Biostatistics Resource at Yale. His studies are funded by several NIH and private foundation awards and have resulted in high impact publications in journals like The Journal of Clinical Investigation, Diabetes and Endocrinology.
Extensive Research Description
- Adaptations of Brain Energy Metabolism to Hypoglycemia
- Regulation of Brain Glucose Metabolism by Alternate Fuels
|Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2, Diseases of the Endocrine System||Development of Agents to Diminish the Risk of Hypoglycemia-induced Brain Injury in Type 1 Diabetes|
|Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2, Diseases of the Endocrine System||Restoring brain metabolism and function in older adult T1DM patients using an AP system|
|Diabetes Mellitus - Type 1, Diseases of the Endocrine System, Diseases of the Nervous System||Impact of Hypoglycemia on Brain Ketone and Neurotransmitter Metabolism in Type 1 DM|
|Aging, Diseases of the Nervous System||Glutathione and the aging brain|
|Children's Health, Diabetes Mellitus - Type 2, Diseases of the Cardiovascular System, Diseases of the Endocrine System, Genetics - Pediatric, Obesity & Weight Control||Prevalence of Carbohydrate Intolerance in Lean and Obese Children|
Diabetes. Can tight glycemic control in diabetes benefit cognition?
Herzog RI, Sherwin RS. Diabetes. Can tight glycemic control in diabetes benefit cognition? Nature Reviews. Neurology 2012, 8:124-6. 2012
Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia.
Herzog RI, Jiang L, Herman P, Zhao C, Sanganahalli BG, Mason GF, Hyder F, Rothman DL, Sherwin RS, Behar KL. Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia. The Journal Of Clinical Investigation 2013, 123:1988-98. 2013
Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor.
Xiang Y, Cheng J, Wang D, Hu X, Xie Y, Stitham J, Atteya G, Du J, Tang WH, Lee SH, Leslie K, Spollett G, Liu Z, Herzog E, Herzog RI, Lu J, Martin KA, Hwa J. Hyperglycemia repression of miR-24 coordinately upregulates endothelial cell expression and secretion of von Willebrand factor. Blood 2015, 125:3377-87. 2015
Quantification of 1H NMR Spectra from Human Plasma.
de Graaf RA, Prinsen H, Giannini C, Caprio S, Herzog RI. Quantification of 1H NMR Spectra from Human Plasma. Metabolomics : Official Journal Of The Metabolomic Society 2015, 11:1702-1707. 2015