Qin Yan, PhD

Associate Professor Tenure; Director, Epigenetics Program

Research Departments & Organizations

Pathology: Pathology Research | Yan Lab

Discovery to Cure Internship

Yale Cancer Center: Genomics, Genetics, and Epigenetics

Yale Stem Cell Center

Office of Cooperative Research

Research Interests

Epigenomics; Gene Expression Regulation; Histone Demethylases; Neoplasm Metastasis; Neoplasms; Neoplastic Stem Cells; Stem Cells

Research Summary

Epigenetic aberrations often lead to cancer and other human diseases. The long-term goal of our laboratory is to elucidate the roles of epigenetic regulation in cancer and to translate our findings to the clinic. In particular, we focus on the epigenetic regulators of cancer metastasis, antitumor immune response and resistance to anticancer drugs. Among these epigenetic regulators, the KDM5/JARID1 histone demethylases are demethylases for tri- methylated lysine 4 in histone H3 (H3K4me3), the epigenetic mark for transcriptionally active chromatin. Using KDM5A/B knockout mouse models, we showed that loss of KDM5A or KDM5B inhibits tumorigenesis in several genetically engineered mouse models. We are currently studying how these epigenetic regulators contribute to cancer initiation and progression using biochemical, molecular biological, cell biological and mouse genetic approaches. As these epigenetic regulators are potential drug targets, we are developing inhibitors against these regulators for cancer treatment.

Specialized Terms: Epigenetics; Gene regulation; Cancer biology

Selected Publications

See list of PubMed publications

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Contact Info

Qin Yan, PhD
Lab Location
Brady Memorial Laboratory
310 Cedar Street, Rm BML338

New Haven, CT 06510
Office Location
Department of PathologyBrady Memorial Laboratory
310 Cedar Street, Rm BML348C

New Haven, CT 06510
Mailing Address
Pathology310 Cedar Street, BML348C
PO Box 208023

New Haven, CT 06520-8023

Yan lab