Research Departments & Organizations
Rheumatic Diseases Research Core
Anemia, Sickle Cell; Diseases; Elliptocytosis, Hereditary; Erythropoiesis; Genetics; Genomics; Health Care; Hydrops Fetalis; Information Science; Neonatology; Pathology; Pediatrics; Spherocytosis, Hereditary
Dr. Gallagher’s research focuses on normal and perturbed hematopoiesis. His primary focus is the genetic basis of inherited disorders of hematopoiesis, with a special interest in disorders of the erythrocyte the erythrocyte and the molecular control of erythropoiesis. Dr. Gallagher’s research is funded by the NIH and private foundations. Dr. Gallagher is co-director of the Yale Cooperative Center for Excellence in Hematology. Dr. Gallagher is fully engaged in the Yale scientific community, with joint appointments in Pathology and Genetics, and active membership in the Yale Stem Cell Center. He is director of the Yale Center for Blood Disorders. Current extramural activities include Editorial Board service for the American Journal of Hematology, Pediatric and Developmental Pathology, BMC Pregnancy and Childbirth (Associate Editor), Frontiers in Physiology, and Blood Cells, Molecules and Disease and grant and abstract reviewing for numerous NIH, private foundations, and academic society meetings including PAS. He has served as chair of the NIH Erythrocyte and Leukocyte Biology Study Section (now MCH) and as chair of the American Society of Hematology Scientific Subcommittee on Hemoglobin/Red Cell.
Specialized Terms: Neonatal hematology; Erythropoiesis; Inherited abnormalities of the erythrocyte including metabolic, membrane, and hemoglobin disorders; Sickle cell disease; Hereditary spherocytosis; Elliptocytosis; Pyropoikilocytosis; Stomatocytosis.
Extensive Research Description
Dr. Gallagher has trained numerous undergraduate, graduate and medical students, MD and PhD postdoctoral fellows, and sabbatical faculty. Laboratory graduates hold positions throughout the world and trainees have
received awards and honors from local, regional, and national organizations. In addition to serving as the PI on the Yale Neonatal/Perinatal Medicine T32 training grant, he participates in training grants in Genetics, Pathology and Medicine. He serves on the Department of Pediatrics Scholarship Oversight Committee (SOC). He has served on numerous individual SOCs as member or chair, as well as various medical and graduate school mentoring committees, PhD thesis
Identification of biologically relevant enhancers in human erythroid cells.
Su MY, Steiner LA, Bogardus H, Mishra T, Schulz VP, Hardison RC, Gallagher PG. Identification of biologically relevant enhancers in human erythroid cells. The Journal Of Biological Chemistry 2013, 288:8433-44. 2013
The common hereditary elliptocytosis-associated α-spectrin L260P mutation perturbs erythrocyte membranes by stabilizing spectrin in the closed dimer conformation.
Harper SL, Sriswasdi S, Tang HY, Gaetani M, Gallagher PG, Speicher DW. The common hereditary elliptocytosis-associated α-spectrin L260P mutation perturbs erythrocyte membranes by stabilizing spectrin in the closed dimer conformation. Blood 2013, 122:3045-53. 2013
A tissue-specific chromatin loop activates the erythroid ankyrin-1 promoter.
Yocum AO, Steiner LA, Seidel NE, Cline AP, Rout ED, Lin JY, Wong C, Garrett LJ, Gallagher PG, Bodine DM. A tissue-specific chromatin loop activates the erythroid ankyrin-1 promoter. Blood 2012, 120:3586-93. 2012
Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis.
Zarychanski R, Schulz VP, Houston BL, Maksimova Y, Houston DS, Smith B, Rinehart J, Gallagher PG. Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis. Blood 2012, 120:1908-15. 2012
Genetic diagnosis of neuroacanthocytosis disorders using exome sequencing.
Walker RH, Schulz VP, Tikhonova IR, Mahajan MC, Mane S, Arroyo Muniz M, Gallagher PG. Genetic diagnosis of neuroacanthocytosis disorders using exome sequencing. Movement Disorders : Official Journal Of The Movement Disorder Society 2012, 27:539-43. 2012
Patterns of histone H3 lysine 27 monomethylation and erythroid cell type-specific gene expression.
Steiner LA, Schulz VP, Maksimova Y, Wong C, Gallagher PG. Patterns of histone H3 lysine 27 monomethylation and erythroid cell type-specific gene expression. The Journal Of Biological Chemistry 2011, 286:39457-65. 2011
Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S.
Stewart AK, Shmukler BE, Vandorpe DH, Rivera A, Heneghan JF, Li X, Hsu A, Karpatkin M, O'Neill AF, Bauer DE, Heeney MM, John K, Kuypers FA, Gallagher PG, Lux SE, Brugnara C, Westhoff CM, Alper SL. Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S. American Journal Of Physiology. Cell Physiology 2011, 301:C1325-43. 2011