Nii Addy, PhD

Associate Professor of Psychiatry

Research Departments & Organizations

Psychiatry: Addy Lab | Connecticut Mental Health Center | Neuroscience Research Training Program (NRTP) | Yale Tobacco Center of Regulatory Science

Cellular & Molecular Physiology

Interdepartmental Neuroscience Program

Office of Cooperative Research

Research Interests

Behavioral Sciences; Electrochemistry; Neurobiology; Psychiatry; Signal Transduction; Substance-Related Disorders

Research Summary

Our research examines the neurobiological mechanisms of reinforcement learning and motivational control and seeks to identify how these mechanisms are altered in psychiatric illnesses, such as substance abuse. In this work, we use an integrative methodological approach that incorporates in vivo electrochemistry (fast scan cyclic voltammetry), in vivo optogenetics and preclinical behavioral analyses. We are currently investigating the neurobiological processes that underlie the ability of reward-associated cues to modulate ongoing behavior. Our recent findings show that midbrain cholinergic mechanisms powerfully regulate cue-induced cocaine-seeking behavior and suggest that cholinergic receptor modulation of phasic dopamine signaling may be critical for this behavior. Through ongoing projects, we are continuing to examine the role of cholinergic and dopaminergic mechanisms in cue-induced drug-seeking. In other work, we are investigating phasic dopamine mechanisms in nicotine addiction and the potential ability of tobacco product additives to enhance nicotine reinforcement through the regulation of dopamine signaling. In addition to our drug addiction research, we are also determining the role of cholinergic and dopaminergic mechanisms in other psychiatric illnesses, such as major depressive disorder (MDD). The goals of our research are to provide new insight into the mechanistic basis of these complex behaviors and to identify novel therapeutic targets to treat psychiatric disorders.

Specialized terms: Neurobiology of addiction; In vivo electrochemistry; Behavioral pharmacology; Systems neuroscience; Neurotransmission; Signal transduction

Selected Publications

See list of PubMed publications

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