Narendra Wajapeyee, PhD

Associate Professor of Pathology

Research Departments & Organizations

Pathology: Pathology Research | Wajapeyee Lab

Diabetes Research Center

Liver Center

Obesity Research Working Group

Yale Cancer Center: Signal Transduction

Office of Cooperative Research

Research Interests

Carcinogenesis; Carcinoma, Hepatocellular; Disease Progression; Genetics; Hematologic Neoplasms; Lung Neoplasms; Melanoma; Pancreatic Neoplasms; Pathology; Phenomena and Processes

Research Summary

Cancer is a complex disease and typically involves multiple gene-specific and global genetic and epigenetic changes in human genome. The major classes of genes that have been causally linked to the process of tumorigenesis are  tumor suppressors, which act as a “brakes”, and oncogenes, which function as “accelerators” and typically promote cancer. Recently, non-coding RNAs such as miRNAs and long non-coding RNAs are also linked to cancer, wherein they can either promote or inhibit cancer cell growth. The focus of our lab is to understand the mechanisms of genetic and epigenetic regulation of cancer initiation and progression and translating this understanding for early detection and treatment of human cancers. We use melanoma, pancreatic cancer, lung cancer, hepatocellular carcinoma and hematological malignancies as model systems to study mechanism of tumor initiation and progression.

Specialized Terms: Genetic and epigenetic mechanisms of cancer initiation and progression

Selected Publications

See list of PubMed publications

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Contact Info

Narendra Wajapeyee, PhD
Lab Location
Brady Memorial Laboratory
310 Cedar Street, Ste BML 363

New Haven, CT 06510
Office Location
Brady Memorial Laboratory
310 Cedar Street, Ste BML 137

New Haven, CT 06510
Mailing Address
Pathology310 Cedar Street
PO Box 208023

New Haven, CT 06520-8023

Wajapeyee Lab