Michelle Hampson, PhD

Associate Professor of Radiology and Biomedical Imaging and of Psychiatry and in the Child Study Center; Director of real-time fMRI

Research Departments & Organizations

Radiology & Biomedical Imaging: Bioimaging Sciences: Magnetic Resonance Imaging; Magnetic Resonance Research Center

Obsessive Compulsive Disorder Research Clinic

Office of Cooperative Research

Research Interests

Magnetic Resonance Imaging; Neurofeedback; Neurosciences; Obsessive-Compulsive Disorder; Psychiatry and Psychology; Stress Disorders, Post-Traumatic; Video Games

Research Summary

My lab is focused on the development and application of new functional brain imaging paradigms. These include resting state functional connectivity analyses and neurofeedback via real-time fMRI (rt-fMRI). Rt-fMRI neurofeedback has great potential as a clinical treatment for mental and neurological disorders. When used in conjunction with resting state functional connectivity assessments (collected before and after the neurofeedback), it provides a powerful perturb-and-measure approach for studying human brain function.

Extensive Research Description

1. We use neurofeedback of real-time fMRI data to train patients with tic disorders, OCD, and PTSD to control clinically relevant brain activity patterns. An important question is whether this training can improve their symptoms.

2. We evaluate changes in resting state functional connectivity between brain areas before and after neurofeedback. This allows us to investigate how neurofeedback alters brain networks. Also, by correlating changes in brain connectivity with symptom changes, we can gain insight into the neural circuitry that gives rise to symptoms.

3. We are examining the neural and mental correlates of video game playing in adolescents.

Clinical Trials

Conditions Study Title
Diseases of the Nervous System, Mental Health & Behavioral Research Neurofeedback of Amygdala Activity for Post-traumatic Stress Disorder (PTSD)
Child Development & Autism, Children's Health, Mental Health & Behavioral Research CBT for Anxiety in Children With Autism
Diseases of the Nervous System, Mental Health & Behavioral Research Biomarkers of Clinical Subtype and Treatment Response in Obsessive-Compulsive Disorder
Diseases of the Nervous System, Mental Health & Behavioral Research Neurofeedback for Obsessive-Compulsive Disorder

Activities

  • Biomarkers of neurofeedback response Montreal, Canada (2018)

  • Timecourse of clinical change induced by neurofeedback Kyoto, Japan (2017)

  • Brain correlates of success and failure during feedback learning Gainesville, United States (2015)

  • Real-time fMRI neurofeedback for treating and studying obsessive-compulsive symptoms. Trapani, Italy (2014)

  • Real-time fMRI neurofeedback for treating and studying obsessive-compulsive symptoms. Yokohama, Japan (2014)

  • Optimization of real-time fMRI neurofeedback. Boston, United States (2013)

  • Real-time fMRI biofeedback. New Haven, United States (2013)

  • Exploratory, voxel-wise measures of connectivity Magdeburg, Germany (2012)

  • Biofeedback of real-time fMRI data from the orbitofrontal cortex to reduce contamination anxiety Whistler, Canada (2012)

  • Relating variations in network connectivity to cognitive function San Diego, United States (2010)

  • Modulating Functional Connectivity Milwaukee, United States (2010)

  • Relationships between behavior and functional connectivity in the brain Trapani, Italy (2009)

  • Brain Connectivity and Behavior Magdeburg, Germany (2008)

  • Relating function to connectivity Barcelona, Spain (2007)

Selected Publications

See list of PubMed publications

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