Michael Schilsky, MD

Professor of Medicine; Medical Director, Adult Liver Transplant at Yale-New Haven Transplantation Center

Research Departments & Organizations

Internal Medicine: Digestive Diseases

Office of Cooperative Research

Research Interests

Copper; Liver Failure, Acute; Liver Transplantation

Research Summary

I participate as an investigator in the NIH sponsored Acute Liver Failure Study Group. I am an investigator in clinical trials for patients with Wilson disease and advanced liver disease.

Extensive Research Description

I participate as an investigator in the NIH sponsored Acute Liver Failure Study Group where we have been focusing on patients with acute liver failure to advance our understanding of this uncommon disorder.

I am an investigator in clinical trials for patients with Wilson disease, including the testing of once daily use of trientine for maintenance therapy, and the novel agent WTX 101 (choline-tetrathiomolybdate).


Clinical Trials

Conditions Study Title
Diseases of the Digestive System - Liver 13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF (ALFSG-MBT)
Diseases of the Nervous System Trientine Tetrahydrochloride (TETA 4HCL) for the Treatment of Wilson's Disease
Genetics - Adult Efficacy and Safety of WTX101 Administered for 48 Weeks Versus Standard of Care in Wilson Disease Subjects
Diseases of the Digestive System - Liver, Diseases of the Eye, Diseases of the Nervous System Wilson Disease Registry
Hepatitis, HIV/AIDS, Immune System, Infectious Diseases Screening In Anticipation of Future Research

Selected Publications

  • ICU management of acute liver failure.

    Schilsky ML, Honiden S, Arnott L, Emre S. ICU management of acute liver failure. Clinics In Chest Medicine 2009, 30:71-87, viii. 2009

  • Screening for Wilson disease in acute liver failure: a comparison of currently available diagnostic tests.

    Korman JD, Volenberg I, Balko J, Webster J, Schiodt FV, Squires RH, Fontana RJ, Lee WM, Schilsky ML. Screening for Wilson disease in acute liver failure: a comparison of currently available diagnostic tests. Hepatology (Baltimore, Md.) 2008, 48:1167-74. 2008

  • Diagnosis and treatment of Wilson disease: an update.

    Roberts EA, Schilsky ML. Diagnosis and treatment of Wilson disease: an update. Hepatology (Baltimore, Md.) 2008, 47:2089-111. 2008

  • Ala A, Aliu E, Schilsky ML. Once daily trientene for maintenance therapy for Wilson disease.

    Dig Dis Sci 60:1433-1439. 2015

  • Ferenci P, Czlonkowska A, Stremmel W, Houwen R, Rosenberg W, Schilsky M, Jansen P, Moradpour D, Gitlin J. EASL Clinical Practice Guidelines: Wilson's disease.

    European Association for Study of Liver. J Hepatol. 56:671-685 2012

  • Karvellas CJ, Stravitz RT, Battenhouse H, Lee WM, Schilsky ML; for the US Acute Liver Failure Study Group. Therapeutic hypothermia in acute liver failure: A multi-center retrospective cohort analysis.

    Liver Transpl. 21:4-12 2015

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