Mehran Sadeghi, MD

Professor

Research Departments & Organizations

Internal Medicine: Cardiovascular Medicine: Sadeghi Lab; Yale Cardiovascular Clinical Research | Yale Tissue Regeneration and Fibrosis Program

Vascular Biology and Therapeutics Program

Office of Cooperative Research

Research Interests

Analytical, Diagnostic and Therapeutic Techniques and Equipment; Aneurysm; Aortic Aneurysm; Aortic Diseases; Aortic Valve; Aortic Valve Stenosis; Biomedical Technology; Cardiomyopathies; Cardiovascular Diseases; Diagnostic Techniques and Procedures; Diseases; Early Diagnosis; Health Care; Heart Diseases; Industry; Molecular Biology; Molecular Imaging; Molecular Probes; Optical Imaging; Peripheral Vascular Diseases; Positron-Emission Tomography; Radioactive Tracers; Single Photon Emission Computed Tomography Computed Tomography; Technology; Tomography, X-Ray Computed; Vascular Diseases

Research Summary

Molecular imaging provides a unique opportunity to link vascular and molecular biology and imaging, ultimately leading to the development of novel imaging approaches, both for research and clinical diagnostics. The ultimate goal of research in my laboratory is to develop novel imaging approaches to detect the molecular pathobiology of the vessel wall in vivo. Our comprehensive approach includes several components. Through basic vascular biology research we identify relevant molecular processes and potential targets for imaging (and therapeutics). Next, we use the state of the art technology to develop novel tracers targeted at relevant molecular markers, and establish molecular vascular imaging protocols in animal models of human disease. Finally, we exploit these techniques to further advance vascular biology and clinical research. We have made significant progress towards achieving these goals in the past few years. Specifically, we have focused on vascular remodeling, as the prototypic pathological vascular process shared by many vascular diseases, including atherosclerosis, graft arteriosclerosis, post-angioplasty restenosis, and aneurysm formation.

Extensive Research Description

Despite remarkable recent progress in molecular and vascular biology research, little has been achieved in adapting traditional imaging modalities to detect molecular pathobiology in vivo. Molecular imaging provides a unique opportunity to link vascular and molecular biology and imaging, ultimately leading to the development of novel imaging approaches, both for research and clinical diagnostics. The ultimate goal of research in my laboratory is to develop novel imaging approaches to detect the molecular pathobiology of the vessel wall in vivo. Our comprehensive approach includes several components. Through basic vascular biology research we identify relevant molecular processes and potential targets for imaging (and therapeutics). Next, we use the state of the art technology to develop novel tracers targeted at relevant molecular markers, and establish molecular vascular imaging protocols in animal models of human disease. Finally, we exploit these techniques to further advance vascular biology and clinical research. We have made significant progress towards achieving these goals in the past few years. Specifically, we have focused on vascular remodeling, as the prototypic pathological vascular process shared by many vascular diseases, including atherosclerosis, graft arteriosclerosis, post-angioplasty restenosis, and aneurysm formation. Our federally funded studies of the pathophysiology of vascular remodeling in graft arteriosclerosis, performed under the umbrella of the Interdepartmental Program in Vascular Biology and Transplantation at Yale have led to the identification novel molecular markers, including a neuropilin-like protein, ESDN, as a potential target for diagnosis and therapy of vascular remodeling. We have demonstrated that ESDN is upregulated in vascular remodeling, and have defined its function as regulator of vascular cell proliferation in vivo. We are currently in the process of defining other aspects of ESDN function, including its role in growth factor and integrin signaling pathways, and identification of ESDN ligands. In molecular imaging arena, we have identified and validated avß3 integrin activation as a target for imaging the proliferative process in vascular remodeling, and have demonstrated the suitability of avß3-targeted tracers for imaging graft arteriosclerosis. Matrix metalloproteinase (MMP) activation, as a key regulator of vascular remodeling, was targeted for in vivo imaging of injury-induced vascular remodeling and aneurysm formation using high resolution microSPECT imaging in conjunction with CT angiography for anatomical localization. We are currently in the process of optimizing the technical aspects of in vivo microSPECT/CT imaging to improve visualization and quantitation of molecular targets. In parallel, we have developed a novel “tracer design” concept for in vivo applications and have been involved in the development of a novel intravascular detection system which combines scintigraphy with high resolution optical coherence tomography imaging.

  • Molecular Imaging of Vascular and Valvular Remodeling
  • Molecular Imaging of Plaque Vulnerability and Aneurysm
  • Neuropilin-like Proteins in Vascular Remodeling

Clinical Trials

Conditions Study Title
Mental Health & Behavioral Research Imaging Microglial Activation in PTSD wITH PET
Addictive Behaviors, Alcohol Addiction, Mental Health & Behavioral Research, Tobacco Addiction Determining Eligibility for Neuroimaging Research Studies

Selected Publications

See list of PubMed publications

Edit this profile

Contact Info

Mehran Sadeghi, MD
  • Office 203.737.6954
  • Fax 203.737.6118
  • Lab 203.932.5711 x5705
Lab Locations
Yale Cardiovascular Research Center300 George Street, Ste 7th floor
New Haven, CT 06511
Cardiovascular Molecular Imaging LaboratoryVA Connecticut Healthcare
950 Campbell Avenue, Ste Building 2, Room 5226

West Haven, CT 06516
Office Locations
Yale Cardiovascular Research Center300 George Street, Ste 770G
New Haven, CT 06511
VA Connecticut Healthcare
950 Campbell Avenue

West Haven, CT 06516
Mailing Addresses
Cardiovascular Medicine950 Campbell Avenue, #111B
West Haven, CT 06516
Yale Cardiovascular Research Center
300 George Street

New Haven, Connecticut 06511

Curriculum Vitae

Sadeghi Lab