Li Wen, MD, PhD

Associate Professor of Medicine (Endocrinology); Director of Core Laboratory of Yale Center for Clinical Investigation (YCCI)

Research Departments & Organizations

Discovery to Cure Internship

Human and Translational Immunology Program

Internal Medicine: Diabetes Research Center | Fellowship Training

Research Interests

Antigen-Presenting Cells; Antigens, CD20; Autoimmune Diseases; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Diabetes Mellitus, Type 1; Hypersensitivity; Immune Tolerance; Immunity, Humoral; Immunity, Innate; Inflammasomes; Islets of Langerhans; Liver; Microbiota; Obesity; T-Lymphocytes, Regulatory; Toll-Like Receptors

Research Summary

Our research interest lies mainly in autoimmunity, in particular the immunology of type 1 diabetes. Using different animal models, my research group has been trying to understand why immune cells attack insulin producing islet beta cells and how we can prevent this attack and if we can reverse the autoimmune destruction after the disease onset. Our current research topics include 1) the role of innate immunity in type 1 diabetes; 2) the role of gut microbiota in diabetes; 3) the role of B lymphocytes in diabetes; 4) the role of dendritic cells and innate immunity in obesity and diabetes; 5) the role of the inflammasome in diabetes; 6) the role of innate and adaptive immunity in skin allergy; 7) the role of innate and adaptive immunity in liver immunology.

Clinical Trials

Conditions Study Title
Diseases of the Endocrine System Investigating the Role of the Polyol Pathway in the Central Nervous System

Selected Publications

See list of PubMed publications

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