Karla M Neugebauer, PhD

Professor of Molecular Biophysics and Biochemistry and of Cell Biology

Research Departments & Organizations

Cell Biology

Center for RNA Science and Medicine

Yale Cancer Center: Genomics, Genetics, and Epigenetics

Office of Cooperative Research

Research Interests

Alternative Splicing; Biochemistry; Biophysics; Cell Biology; Cell Nucleus; Genomics; Molecular Biology; Nuclear Cap-Binding Protein Complex; RNA Splicing; Saccharomyces cerevisiae; Schizosaccharomyces; Transcription, Genetic; Zebrafish

Research Summary

We are interested in links between in transcription and splicing, as well as the role of cellular subcompartments in RNA biogenesis. We use imaging, techniques that capture RNA-protein interactions, and next generation sequencing as major tools. We study these phenomena in yeast (fission and budding), zebrafish and mammalian tissue culture cells.

Specialized Terms: pre-mRNA splicing, transcription, gene architecture, SR proteins, cap-binding complex, RNA-protein interactions, Cajal bodies, organization of the cell nucleus, zebrafish embryogenesis.

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Contact Info

Karla M Neugebauer, PhD
Mailing Address
333 Cedar St
New Haven, Connecticut 06520

Neugebauer Lab

Higher order organization and functional links among gene expression machineries.

Illustration of the nucleus and cytoplasm of a eukaryotic cell containing nonmembrane-bound cellular bodies, such as nucleoli, Cajal bodies, the histone locus bodies, and P-bodies. Cellular bodies promote molecular interactions by increasing the local concentration of factors. They are often linked to transcription of particular genes (nucleolus: rDNA genes; CB: snRNA genes; histone body locus: histone genes). Similarly, individual machines are rich in RNA polymerase, spliceosomes, RNA-binding proteins and other factors that communicate with one another during gene regulation.