Research Departments & Organizations
Alternative Splicing; Biochemistry; Biophysics; Cell Biology; Cell Nucleus; Genomics; Molecular Biology; Nuclear Cap-Binding Protein Complex; RNA Splicing; Saccharomyces cerevisiae; Schizosaccharomyces; Transcription, Genetic; Zebrafish
We are interested in links between in transcription and splicing, as well as the role of cellular subcompartments in RNA biogenesis. We use imaging, techniques that capture RNA-protein interactions, and next generation sequencing as major tools. We study these phenomena in yeast (fission and budding), zebrafish and mammalian tissue culture cells.
Specialized Terms: pre-mRNA splicing, transcription, gene architecture, SR proteins, cap-binding complex, RNA-protein interactions, Cajal bodies, organization of the cell nucleus, zebrafish embryogenesis.