Research Departments & Organizations
Our laboratory focuses on the role of MAP kinase in bone inflammation. We investigate the novel molecular therapeutic target to prevent or reduce imbalance of osteoclast/osteoblast differentiation by breast cancer metastasis and bacteria infection. To study these processes, we use a translational approach, combining the analysis of human samples and the use of experimental model systems by various immunological and molecular biology state-of-the-art techniques.
Extensive Research Description
The goal of the our research is to introduce a new way of combinational therapy for breast cancer metastasis to bone. Pathologic bone loss related to metastatic cancers and severe osteoporosis affect more than 50% of Americans over the age of fifty. Currently available anti-resorptive drugs such as bisphosphonates do not always effectively preserve or restore bone from the entire array of osteolytic disorders. This presents a barrier which needs to be overcome in order to enhance bone health. Our study enhances the health of patients with severe pathologic bone loss and will create new strategies for treatment of bone metastasis cancers.