Julie Goodwin, MD

Associate Professor of Pediatrics (Nephrology); Fellowship Program Director

Research Departments & Organizations

Pediatrics: Pediatric Nephrology

Rheumatic Diseases Research Core

Vascular Biology and Therapeutics Program

Office of Cooperative Research

Research Interests

Atherosclerosis; Glucocorticoids; Hypertension; Inflammation; Nephrology; Nephrotic Syndrome; Pediatrics; Sepsis; Steroids

Research Summary

The glucocorticoid receptor is found in nearly every cell type. It is the receptor for the body's endogenous steroid (cortisol) as well as for the many synthetic steroids (prednisone, dexamethasone) that are used therapeutically for a variety of conditions. Studies have clearly shown that this receptor has tissue-specific functions and that loss of the receptor in specific tissuess produces profound and unexpected phenotypes. I am interested in determining the role of this receptor in the endothelium, and more recently, in podocytes, the specialized cells which maintain the filtration barrier in the kdiney.

Specialized Terms: Glucocorticoid-induced hypertension; Vascular endothelial glucocorticoid receptor; Steroids and sepsis; Atherosclerosis; Podocyte glucocorticoid receptor and nephrotic syndrome

Extensive Research Description

  • Characterization and mechanism of glucocorticoid-induced hypertension in several mouse models with tissue-specific knockout of the glucocorticoid receptor
  • Effect of the knockout of the glucocorticoid receptor in the endothelium in a mouse model of LPS-induced sepsis, with and without steroid treatment
  • Role of the endothelial glucocorticoid receptor in the development of atherosclerosis and vascular inflammation
  • Role of the podocyte glucocorticoid receptor in the development of nephrotic syndrome

Clinical Trials

Conditions Study Title
Immune System, Infectious Diseases Multicenter, Open Label, Phase 3 Trial of ATA129 for Solid Organ Transplant Subjects With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure of Rituximab or Rituximab and Chemotherapy (ALLELE Study)

Selected Publications

See list of PubMed publications

Edit this profile

Contact Info

Julie Goodwin, MD
Lab Location
Goodwin LabAmistad Street Building
10 Amistad Street, Ste 424

New Haven, CT 06519
Mailing Address
Pediatric NephrologyPO Box 208064
New Haven, CT 06520-8064