Jonathan Grauer, MD

Professor of Orthopaedics and Rehabilitation and Professor of Pediatrics; Interim Chair and Director of Orthopaedic Spine Service of Department of Orthopaedics and Rehabilitation at Yale School of Medicine; Interim Chief of Orthopaedics and Co-Director of Spine Center at Yale New Haven Hospital

Research Departments & Organizations

Orthopaedics & Rehabilitation: Grauer Lab

Research Interests

Anatomy; Health Care; Spine

Research Summary

Dr. Grauer's laboratory performs multiple studies critically evaluating aspects of orthopedic and spine clinical practice.

  • Current clinical research studies
    • Multiple national database outcome studies
    • Multiple cohort studies
  • Current basic / translational science studies
    • None
  • Current clinical trials
    • Pfizer, “Phase 2B, randomized, double-blind, placebo-controlled, study to evaluate the safety and efficacy of staphylococcus aureus 4-antigen (SA4AG) vaccine in adults undergoing elective posterior instrumented lumbar spinal fusion procedures”, co-investigator.
    • Spinal Kinetics, “Concurrently controlled, multi-center study to evaluate the safety and effectiveness of the Spinal Kinetics™ M6-C artificial cervical disc compared to anterior cervical discectomy and fusion (ACDF) for the treatment of symptomatic cervical radiculopathy”, co-investigator.
    • Orthofix, “Safety and efficacy of pulsed electromagnetic fields (Cervical-Stim®) as an adjunct to enhance union in conservatively treated Type II fractures of the odontoid process”, co-investigator
  • Current grants
    • Multiple Yale University School of Medicine Medical Student research supports awards


Extensive Research Description

Dr. Grauer directs an active research group that focuses on clinical outcomes of spine and orthopaedic patients. In an era of striving to optimize patient outcomes, it is crucial that we learn from our patients to advance clinical care.

National databases track large numbers of patients and allow for the study of such outcomes. Dr. Grauer works closely with his student and resident team to draw clinically meaningful messages from large data sets. What patients will do best from an intervention? Which technique is best for which person? Who is at risk for an adverse event? These are just some of the questions being addressed.

As with any type of research, studies based on national databases have both advantages and limitations. Balancing the use of such databases, Dr. Grauer’s team works to delineate the limitation of national database work and strives to optimize studies based on their data. In doing so, they work to draw the most meaningful and valid conclusions possible.

In addition to the above-noted studies, Dr. Grauer’s team is active with studies looking at patients treated locally. With studies evaluating diagnostic imaging modalities, patient characteristics, and patient outcomes, they are able to study more detailed local data.

Overall, Dr. Grauer mentors many Yale medical students and fellows in performing research studies. The team has received multiple awards. He and his group have given over 250 research talks at national and international meetings, and co-authored over 150 peer-reviewed scientific papers.

Activities

  • Ondeck NT, Bohl DD, Bovonratwet P, Geddes BJ, Cui JJ, McLynn RP, Samuel AM, Grauer JN. Adverse events following Anterior Cervical Discectomy and Fusion: A comparison of spine surgeons perceptions and reported data for rates and risk factors. Cervical Spine Research Society, Toronto, December 2016 (E-poster presentation Toronto, Canada (2016)

  • Rihn JA, Bhat S, Harrop JS, Zoher G, Grauer JN, Hilibrand AS. Surgical versus nonsurgical treatment for cervical radiculopathy: a cost effectiveness study. North American Spine Society, Boston, October 2016 (Podium presentation). Boston, United States (2016)

  • Webb ML, Lukasiewicz AM, Samuel AM, Basques BA, Bohl DD, Daubs MD, Grauer JN. Comparison of perioperative adverse event rates after single-level transforaminal lumbar interbody fusion versus anterior/posterior fusion for spondylolytic spondylolisthesis: 30 day outcomes of 635 cases. North American Spine Society, Boston, October 2016 (Podium presentation). Boston, United States (2016)

  • Basques B, Lukasiewicz AM, Samuel A, Webb M, Bohl DD, Ahn J, Singh K, Grauer JN. Missing data may invalidate sine surgery database studies. North American Spine Society, Boston, October 2016 (Podium presentation). Boston, United States (2016)

  • Webb M, Samuel A, Lukasiewicz AM, Geddes BJ, Varthi AG, Grauer JN. Comparison of postoperative adverse events after single-level transformainal lumbar interbody fusion versus anterior/posterior fusion for lumbar spondylosis: 30-day outcomes of 1,274 patients. North American Spine Society, Boston, October 2016 (Poster presentation). Boston, United States (2016)

  • Bovonratwet P, Webb ML, Ondeck NT, Cui JJ, McLynn RP, Kadimcherla P, Kim DH, Grauer JN. Management of degenerative spondylolisthesis: analysis of a questionnaire study, correlation with a national sample, and perioperative outcomes of treatment options. Yale Center for Clinical Investigation Scholar Day Retreat, New Haven, October (Poster presentation). New Haven, United States (2016)

  • Anandasivam NS, Ondeck NT, Samuel AM, Swallow MS, Fischer JM, Chung SH, Bohl DD, Grauer JN. Pediatric femoral shaft fractures: a study of associated injuries by mechanism of injury. American Orthopaedic Association, Seattle, June 2016 (Poster presentation). Seattle, United States (2016)

  • Anandasivam NS, Ondeck NT, Samuel AM, Bohl DD, Swallow MS, Fischer JM, Chung SH, Grauer JN. Demographics and associated injuries of talus fractures: analysis of 9,604 patients. American Orthopaedic Association, Seattle, June 2016 (Poster presentation). Seattle, United States (2016)

  • Webb ML, Lukasiewicz AM, Samuel AM, Basques BA, Bohl DD, Daubs MD, Grauer JN. Comparison of perioperative adverse event rates after single-level transforaminal lumbar interbody fusion versus anterior/posterior fusion for spondylolytic spondylolisthesis: 30 day outcomes of 635 cases. Lumbar Spine Research Society, Chicago, April 2016 (Poster presentation). Chicago, United States (2016)

  • Samuel AM, Fu MC, Anandasivam NS, Lukasiewicz AM, Webb ML, Kim HJ, Grauer JN. Operative time better predictor of perioperative outcomes after long posterior fusions for adult spinal deformity than other surgical variables. International Society for the Advancement of Spine Surgery, Las Vegas, April 2016 (Podium presentation). Las Vegas, United States (2016)

  • Fu MC, Samuel AM, Sheha ED, Derman PD, Iyer S, Grauer JN, Kim HJ. Outpatient procedures reduce short-term complications in one- and two-level anterior cervical discectomy and fusion: A propensity-adjusted analysis of 14,434 patients. International Society for the Advancement of Spine Surgery, Las Vegas, April 2016 (Podium presentation Las Vegas, United States (2016)

  • Samuel AM, Toy JO, Fu MC, Lukasiewicz AM, Webb ML, Bohl DD, Basques BA, Albert TJ, Grauer JN. Most 30-day readmissions after anterior cervical discectomy and fusion are not due to surgical site-related issues: An analysis of 10,006 patients. International Society for the Advancement of Spine Surgery, Las Vegas, April 2016 (Podium presentation). Las Vegas, United States (2016)

  • Samuel AM, Diaz-Collado PJ, Gala R, Webb ML, Lukasiewicz AM, Basques BA, Bohl DD, Grauer JN. Thromboembolic events after traumatic lumbar vertebral fractures: an analysis of 80,558 patients. International Society for the Advancement of Spine Surgery, Las Vegas, April 2016 (Podium presentation). Las Vegas, United States (2016)

  • Bohl DD, Ahn J, Massel D, Mayo B, Basques BA, Singh K, Grauer JN. Impact of operative time on adverse events following anterior cervical discectomy and fusion. International Society for the Advancement of Spine Surgery, Las Vegas, April 2016 (Podium presentation). Las Vegas, United States (2016)

  • Fu MC, Samuel AM, Sheha ED, Derman PD, Iyer S, Grauer JN, Kim HJ. Outpatient procedures reduce short-term complications in one- and two-level anterior cervical discectomy and fusion: A propensity-adjusted analysis of 14,434 patients. International Society for the Advancement of Spine Surgery, Las Vegas, April 2016 (Podium presentation). Las Vegas, United States (2016)

  • Webb M, Lukasiewicz A, Samuel A, Save A, Geddes B, Diaz-Collado P, Grauer JN. Of 12,567 lumbar discectomies, 2.5% of patients readmitted within 30 days: postoperative pain is the most common reason for readmission. International Society for the Advancement of Spine Surgery, Las Vegas, April 2016 (Poster presentation). Las Vegas, United States (2016)

  • Webb M, Samuel A, Lukasiewicz A, Geddes B, Sace A, Diaz-Collado P, Grauer JN. Of 5,267 lumbar posterior fusions, 4.6% of patients readmitted within 30 Days: surgical site issues the most common reasons for readmission.  International Society for the Advancement of Spine Surgery, Las Vegas, April 2016 (Poster presentation). Las Vegas, United States (2016)

  • Basques BA, Samuel AM, Webb ML, Lukasiewicz AM, Ahn J, Bohl DD, Singh K, Grauer JN. Missing data may invalidate spine surgery database studies.  Lumbar Spine Research Society, Chicago, April 2016 (Podium presentation). Chicago, United States (2016)

  • Ondeck NT, Anandasivam NS, Samuel AM, Bohl DD, Grauer JN. Demographics, mechanisms of injury and concurrent injuries associated with lumbar spine injuries: a study of 82,223 patients. Lumbar Spine Research Society, Chicago, April 2016 (Poster presentation). Chicago, United States (2016)

  • Samuel AM, Fu MC, Anandasivam NS, Lukasiewicz AM, Webb ML, Kim HJ, Grauer JN. Surgical timing, and not surgical invasiveness, is predictive of perioperative outcomes after long posterior fusions for adult spinal deformity: A need for speed? Lumbar Spine Research Society, Chicago, April 2016 (Podium presentation). Chicago, United States (2016)

  • Bovonratwet P, Webb ML, Ondeck NT, Grauer JN. Publication rate of abstracts presented at LSRS meetings is similar or greater than that of other spine meetings. Lumbar Spine Research Society, Chicago, April 2016 (Podium presentation). Chicago, United States (2016)

  • Basques BA, Samuel AM, Webb ML, Lukasiewicz AM, Ahn J, Bohl DD, Singh K, Grauer JN. Missing data may invalidate spine surgery database studies. American Academy of Orthopaedic Surgeons, Orlando, March 2016 (Podium presentation). Orlando, United States (2016)

  • Bohl DD, Samuel AM, Webb ML, Lukasiewicz AM, Basques BA, Levine BR, Grauer JN. Timing of complications following total joint arthroplasty. American Academy of Orthopaedic Surgeons, Orlando, March 2016 (Podium presentation). Orlando, United States (2016)

  • Basques BA, Fischer J, Samuel AM, Webb ML, Lukasiewicz AM, Bohl DD, Grauer JN. Missing data significantly affects results from total joint arthroplasty database studies.  American Academy of Orthopaedic Surgeons, Orlando, March 2016 (Poster presentation). Orlando, United States (2016)

  • Samuel AM, Webb ML, Lukasiewicz AM, Bohl DD, Basques BA, Russo GS, Rathi VK, Grauer JN. Large disparities in industry payments to orthopaedic surgeons seen in Sunshine Act data. American Academy of Orthopaedic Surgeons, Orlando, March 2016 (Poster presentation). Orlando, United States (2016)

  • Samuel AM, Lukasiewicz AM, Webb ML, Bohl DD, Basques BA, Varthi AG, Leslie MP, Grauer JN. Do we really understand the patient populations in national databases when doing trauma research? American Academy of Orthopaedic Surgeons, Orlando, March 2016 (Poster presentation). Orlando, United States (2016)

  • Samuel AM, Rathi VK, Grauer JN, Ross JS. Post-market changes to orthopaedic devices cleared via the FDA premarket approval supplement pathway. American Academy of Orthopaedic Surgeons, Orlando, March 2016 (Podium presentation). Orlando, United States (2016)

  • Basques BA, Samuel AM, Webb ML, Lukasiewicz AM, Ahn J, Bohl DD, Singh K, Grauer JN. Missing data may invalidate spine surgery database studies.  American Academy of Orthopaedic Surgeons, Orlando, March 2016 (Podium presentation). Orlando, United States (2016)

  • Bohl DD, Samuel AM, Lukasiewicz AM, Webb ML, Basques BA, Della Valle CJ, Levine BR, Grauer JN. Which adverse events are associated with revision versus primary total joint arthroplasty? American Academy of Orthopaedic Surgeons, Orlando, March 2016 (Podium presentation). Orlando, United States (2016)

Selected Publications

See list of PubMed publications

Edit this profile

Contact Info

Jonathan Grauer, MD
Office Location
Administrative Office47 College Street
New Haven, CT 06510
Mailing Address
Orthopaedics & RehabilitationP.O. Box 208071
New haven, CT 06520-8071