Jonathan Koff, MD

Associate Professor Term; Director, Adult Cystic Fibrosis Program

Research Departments & Organizations

Internal Medicine: CPIRT - Pulmonary Infection Research and Treatment | Koff Laboratory | Liver Center

Office of Cooperative Research

Research Interests

Asthma; Bronchiectasis; Cystic Fibrosis; Influenza, Human; Lung; Respiratory Mucosa; Viruses

Research Summary

The airways are continuously exposed to pathogens, allergens, toxins, and environmental contaminants. In addition to its role as a physical barrier, the airway epithelial surface represents a “battleground,” where the host intercepts signals from pathogens (e.g., viruses) and activates epithelial defenses to prevent infection. The defensive roles of the airway epithelium are crucial; the epithelium activates innate defense mechanisms and recruits inflammatory and immune cells to activate innate immune responses and to amplify adaptive immunity. Our research program focuses on elucidating airway epithelial inflammatory responses to viral infection. Utilizing both in vitro and ex vivo airway epithelial cell cultures and murine models, we have found novel signaling pathways which regulate viral infection. Currently, there are only limited therapies available to treat viral exacerbations of chronic airway diseases (e.g., asthma, COPD, and cystic fibrosis); therefore investigating novel viral mechanisms may provide targets for novel therapies.

Clinical Trials

Conditions Study Title
Children's Health, Genetics - Pediatric Testing the Effect of Adding Chronic Oral Azithromycin to Inhaled Tobramycin in People With CF (TEACH)
Genetics - Adult, Genetics - Pediatric A Study Evaluating the Long Term Safety and Efficacy of VX-659 Combination Therapy
Genetics - Adult, Genetics - Pediatric A Phase 3 Study of VX-659 Combination Therapy in Subjects With Cystic Fibrosis Heterozygous for the F508del Mutation and a Minimal Function Mutation (F/MF)
Diseases of the Lung, Diseases of the Respiratory Systems Standardized Treatment of Pulmonary Exacerbations II (STOP2)
Hepatitis, HIV/AIDS, Immune System, Infectious Diseases Screening In Anticipation of Future Research
Children's Health, Diseases of the Respiratory Systems G551D Observational Study- Expanded to Additional Genotypes and Extended for Long Therm Follow up (GOAL-e2) (GOAL- e2)

Selected Publications

See list of PubMed publications

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Contact Info

Jonathan Koff, MD
Lab Location
The Anlyan Center
300 Cedar Street, Ste S430

New Haven, CT 06519
Office Location
The Anlyan Center
300 Cedar Street, Ste S455C

New Haven, CT 06519
Mailing Address
PO Box 208057
300 Cedar Street

New Haven, CT 06520-8057

Koff Laboratory