John Krystal, MD

Robert L. McNeil, Jr. Professor of Translational Research and Professor of Psychiatry and of Neuroscience; Chair, Department of Psychiatry; Chief of Psychiatry, Yale-New Haven Hospital; Director: NIAAA Center for the Translational Neuroscience of Alcoholism; Director, Clinical Neuroscience Division, VA National Center for PTSD

Research Departments & Organizations

Psychiatry: Center for the Translational Neuroscience of Alcoholism | Clinical Neuroscience Research Unit | Neurocognition, Neurocomputation, and Neurogenetics, Division of | Neuroscience Research Training Program (NRTP) | Obsessive Compulsive Disorder Research Clinic

Diabetes Research Center

Drug use, Addiction, and HIV Research Scholars (DAHRS)

Interdepartmental Neuroscience Program

Department of Psychology

Office of Cooperative Research

Research Interests

Alcoholism; Drug Therapy; Genetics; Neurobiology; Neuroimaging; Psychiatry; Schizophrenia; Stress Disorders, Post-Traumatic; Veterans

Research Summary

Neurobiology; pharmacotherapy; genetics; neuroimaging; computational neuroscience

schizophrenia; alcoholism; PTSD; depression

Clinical Trials

Conditions Study Title
Diseases of the Nervous System, Mental Health & Behavioral Research Examination of Glutamate and mGluR5 in Psychiatric Disorders
Mental Health & Behavioral Research Imaging 11B-hydroxysteroid dehydrogenase availability in vivo
Mental Health & Behavioral Research Evaluation of glutamate levels in adolescent mood disorders
Mental Health & Behavioral Research Imaging Microglial Activation in PTSD wITH PET
Mental Health & Behavioral Research Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response
Mental Health & Behavioral Research Mavoglurant in Alcohol Drinking
Diseases of the Nervous System, Genetics - Adult, Genetics - Pediatric, Mental Health & Behavioral Research Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)
Mental Health & Behavioral Research Imaging mGluR5 and synaptic density in psychiatric disorders
Addictive Behaviors, Alcohol Addiction, Mental Health & Behavioral Research Saracatinib and Alcohol Drinking
Mental Health & Behavioral Research Examining the Impact of Sirolimus on Ketamine's Antidepressant Effects
Diseases of the Nervous System, Mental Health & Behavioral Research Biomarkers of Clinical Subtype and Treatment Response in Obsessive-Compulsive Disorder
Addictive Behaviors PET Imaging of mGLuR5 With Drug Challenge
Mental Health & Behavioral Research Translational Neuroscience Optimization of GlyT1 Inhibitor (NCATS)
Addictive Behaviors, Alcohol Addiction, Genetics - Adult, Mental Health & Behavioral Research Ability of Partial Inverse Agonist, Iomazenil, to Block Ethanol Effects in Humans


  • Schizophrenia Treatment Taichung, Taiwan (2013 - 2014)

    Consulting regarding novel treatments for schizophrenia and ketamine-related psychosis.

  • Neuroimaging studies of schizophrenia and related disorders Chengdu, China (2012 - 2014)

    Neuroimaging studies of brain structure and function associated with psychosis

  • Rapid Acting Antidepressant Treatment Taipei, Taiwan (2012 - 2014)

    Consulting to a study conducted evaluating the antidepressant effects of ketamine, led by Dr. Tung-Ping (Tom) Su.

  • Studies of the impact of sexual trauma Bergen, Norway (2011 - 2016)

    I am collaborating with Iris Steine, a Ph.D. candidate at the University of Bergen, as well has her mentors and colleagues, on studies on the clinical features and neurobiology of sexual trauma and its complications, including PTSD

  • Ketamine Psychosis Guangzhou, China (2010 - 2014)

    Studying the phenomenology and genetics of ketamine psychosis in relation to schizophrenia

  • Clinical Archives Project Cherite Hospital Berlin, Germany (2006 - 2014)

    The Department of Psychiatry at Cherite Hospital in Berlin has long been a home to ethical and compassionate treatment of patients. However, in the period leading up to World War II, its psychiatry leadership involved the hospital in the emerging eugenics movement. This work, contributed to the...

Selected Publications

See list of PubMed publications

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