Joerg Bewersdorf, PhD

Professor of Cell Biology and of Biomedical Engineering

Research Departments & Organizations

Cell Biology

Diabetes Research Center

Kavli Institute for Neuroscience

Office of Cooperative Research

Research Interests

Cell Nucleus; Cellular Structures; Endoplasmic Reticulum; Microscopy, Confocal; Microscopy, Fluorescence

Research Summary

Visualizing 3D structure and dynamics at the molecular scale is a current and critical need in biomedical research. Many sub-cellular features, for example the morphology of many organelles or the 3D organization of chromatin, cannot be resolved by standard light microscopy.

Improving the resolution of light microscopy has therefore been an urgent need of biological research for many decades. Today, several methods achieve sub-100 nm resolution by taking advantage of reversible or irreversible photo-physical switching properties of fluorescent markers.

Our research group in the Department of Cell Biology at Yale University School of Medicine is developing new fluorescence microscopy techniques with spatial and/or temporal resolutions exceeding far beyond current technology and also applying them to a diverse set of biological questions.

Specialized Terms: Super-resolution fluorescence microscopy

Extensive Research Description

Our laboratory works on both Stimulated Emission Depletion (STED) microscopy and Fluorescence Photoactivation Localization Microscopy (FPALM/PALM/etc.) techniques. We are actively developing to improve the speed, the 3D resolution and the depth penetration of these imaging techniques to expand the application range of super-resolution microscopy. In collaboration with a diverse set of research groups at Yale University and outside, we apply our new instruments to current biomedical questions.

We are currently working on multiple projects to further improve fluorescence imaging technology and applying these cutting-edge techniques to current biological questions.

Selected Publications

See list of PubMed publications

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Contact Info

Joerg Bewersdorf, PhD
Lab Location
Sterling Hall of Medicine, I-Wing
333 Cedar Street, Ste E91

New Haven, CT 06510
Office Location
Sterling Hall of Medicine, I-Wing
333 Cedar Street, Ste Suite E54B

New Haven, CT 06510
Mailing Address
Cell BiologyPO Box 208002
333 Cedar Street

New Haven, CT 06520-8002

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