James Rothman, PhD

Sterling Professor of Cell Biology and Professor of Chemistry; Chairman, Department of Cell Biology; Director, Nanobiology Institute

Research Departments & Organizations

Cell Biology: Membrane Traffic | Rothman Lab

Diabetes Research Center

Fellowship Training

Liver Center

Research Interests

Biochemistry; Biophysics; Cell Biology; Chemistry; Golgi Apparatus; Membrane Fusion; Synaptic Transmission; Vesicular Transport Proteins

Research Summary

We take an interdisciplinary approach, which includes cell-free biochemistry, single molecule biophysics, and super-resolution optical imaging of single events/single molecules in the cell and in cell-free formats. The overall goal is to understand transport pathways form structural mechanism to cellular physiology. We have a strong interest in new lab members who bring backgrounds in protein biochemistry, organic chemistry, biophysics, and bio-engineering.

Specialized Terms: Elucidating the underlying mechanisms of vesicular transport within cells; Secretion of hormones and neurotransmitters

Extensive Research Description

  1. The biophysical mechanisms of membrane fusion.
  2. Regulation of vesicle fusion in synaptic transmission.
  3. Structural and functional organization of the Golgi apparatus.

Selected Publications

See list of PubMed publications

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Contact Info

James Rothman, PhD
Lab Location
Rothman LaboratorySterling Hall of Medicine, C-Wing
333 Cedar Street, Ste SHM C-434

New Haven, CT 06510
Mailing Address
Cell Biology333 Cedar Street
P.O. Box 208002

New Haven, CT 06520-8002

Rothman Lab