Imran Quraishi, MD, PhD

Assistant Professor

Research Departments & Organizations

Neurology

Research Interests

Biomedical Engineering; Channelopathies; Computational Biology; Electroencephalography; Epilepsy; Ion Channels; Seizures

Research Summary

I am an epileptologist interested in ion channels in epilepsy. Working with Dr. Leonard Kaczmarek, I am using a combination of cellular electrophysiology, animal models, and computational simulations to study epilepsy-associated potassium channels. I am also interested in applications of technology such as medical devices to epilepsy care.

Extensive Research Description

Potassium channels in epilepsy

  • Recordings of mutant and wild type Slack (KCNT1) neuronal potassium currents in different types of neurons and induced pluripotent stem cells.
  • EEG and behavioral tests in animal models derived from patients with epilepsy-associated potassium channel mutations to characterize seizures, learning abnormalities, and the response to new drugs.
  • Computational models of epilepsy to determine the effects of changes in ion channel function on seizure initiation and dynamics.

Clinical projects

  • Analysis of data from the NeuroPace responsive neurostimulator (RNS), a pacemaker-like device that is implanted into the brain to treat epilepsy.
  • Setting up widespread genetic testing in the Yale Epilepsy Center to find genetic variants that may predispose patients to epilepsy.

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Contact Info

Imran Quraishi, MD, PhD
Mailing Address
NeurologyP.O. Box 208018
Yale Epilepsy Center

New Haven, CT 06520-8018