Imran Quraishi, MD, PhD

Assistant Professor

Research Departments & Organizations


Research Interests

Biomedical Engineering; Channelopathies; Computational Biology; Electroencephalography; Epilepsy; Ion Channels; Seizures

Research Summary

I am an epileptologist interested in ion channels in epilepsy. Working with Dr. Leonard Kaczmarek, I am using a combination of cellular electrophysiology, animal models, and computational simulations to study epilepsy-associated potassium channels. I am also interested in applications of technology such as medical devices to epilepsy care.

Extensive Research Description

Potassium channels in epilepsy

  • Recordings of mutant and wild type Slack (KCNT1) neuronal potassium currents in different types of neurons and induced pluripotent stem cells.
  • EEG and behavioral tests in animal models derived from patients with epilepsy-associated potassium channel mutations to characterize seizures, learning abnormalities, and the response to new drugs.
  • Computational models of epilepsy to determine the effects of changes in ion channel function on seizure initiation and dynamics.

Clinical projects

  • Analysis of data from the NeuroPace responsive neurostimulator (RNS), a pacemaker-like device that is implanted into the brain to treat epilepsy.
  • Setting up widespread genetic testing in the Yale Epilepsy Center to find genetic variants that may predispose patients to epilepsy.

Clinical Trials

Conditions Study Title
Diseases of the Nervous System, Mental Health & Behavioral Research SV2A PET Imaging in Healthy Subjects and Epilepsy Patients

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Contact Info

Imran Quraishi, MD, PhD
Mailing Address
NeurologyP.O. Box 208018
Yale Epilepsy Center

New Haven, CT 06520-8018