Hyuk-Kwon Kwon, PhD

Postdoctoral Associate

Research Departments & Organizations

Orthopaedics & Rehabilitation

Research Interests

Apoptosis; Bacterial Infections; Cell Survival; Chemokines; Chemotherapy, Adjuvant; Cytokines; DNA Damage; Gram-Negative Bacteria; Gram-Positive Bacteria; Inflammasomes; Inflammation; Methicillin-Resistant Staphylococcus aureus; Necrosis; Staphylococcus aureus; Toll-Like Receptors; Toxicology

Research Summary

Infection and Bone Destruction Study

  1. The study of the mechanism of bone inflammation via S. aureus infection after bone surgery which aims the discovery of the biomarker for a bone infection.
  2. The development of the small molecular drugs for combination with antibiotics which aims the reduction of the failure of bone surgery due to infection.

Innate Immune Systems & Inflammasome Study

  1. The discovery of the Toll-like receptors (TLRs)- and inflammasome-targeting molecules such as peptide and chemical which aim the suppression of the TLRs- and inflammasome-mediated production of pro-inflammatory cytokine and the reduction of the generation of oxidative stress in immune disease models.
  2. The studies of TLRs and inflammasome signaling pathway, the induced production pro-inflammatory cytokine and oxidative stress including reactive oxygen species (ROS) and nitric oxide (NO) generations, upon the signaling pathway’s activation.

Toxicology

Cell Death (apoptosis, necrosis and necroptosis)

  1. The use of microarray database and software for the selection and classification of biomarkers and candidate-molecules in carcinogenesis and cell death.
  2. The studies of chemotherapy drug and their effect on the cell death including apoptosis, necrosis and necroptosis, the regulation DNA damage, cell cycle, DNA damage repair, MAPKs and cell death signalling pathways.
  3. The mechanisms of p53 mediates apoptosis and antiapoptosis, poly (ADP-ribose) polymerase 1 (PARP1) mediates necrosis and the activation of transcription factor 3 (ATF3) mediates cell death by chemotherapy drugs.
  4. The mechanisms and functions of mitochondrial dynamics including mitochondrial biogenesis and disruption, and generation of reactive oxygen species (ROS) and nitric oxide (NO) during chemotherapy drug-induced cell death.

Systems Biology & Application of Nanotechnology Studies

  1. The analysis of microarray for a better understanding of the cellular response and the signalling pathway activity during the cellular responses such as TLRs and chemotherapy drug-induced cell death.
  2. The analysis of microarray for the selection and classification of therapeutic candidates, using various databases and software which predicts molecules related with the signalling pathway.
  3. Understanding of cellular response such as alteration of morphology, nuclear envelope and cell adhesion using various nanotechnology such as atomic force microscopy, ion conductance microscopy and electrochemical biosensor. Study of cells differentiation and proliferation using a 3D culture system that regulates cellular response and signalling pathway.

Selected Publications

See list of PubMed publications

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Contact Info

Hyuk-Kwon Kwon, PhD
Lab Location
Orthopaedics & RehabilitationTompkins Memorial Pavilion
789 Howard Avenue, Fl 5 Rm 509

New Haven, CT 06519
Mailing Address
Orthopaedics & Rehabilitation330 Cedar Street
Tompkins Memorial Pavilion 509

New Haven, Connecticut 06520-8071

Curriculum Vitae

Cover illustration

Cover illustration: Toxicol Sci (2015) 148