Research Departments & Organizations
Psychiatry: Division of Women's Behavioral Health Research | Mood Disorders Research Program | Neuroscience Research Training Program (NRTP) | Psychotherapy Development Center | Stress & Addiction Clinical Research Program
Obesity Research Working Group
A focus of Dr. Blumberg's laboratory is the use of brain scanning techniques to elucidate the differences in brain circuitry that underlie mood disorders, and how these differences develop in children and adolescence and change over the lifespan into later life. The goal of the research is identify causes of the disorders to design improved treatments and preventive strategies to decrease the suffering and high risk of suicide associated with the disorders.
The lab is working intensively on genetic and environmental factors that may contribute to the brain differences and that may point to new prevention and treatment strategies. Brain scanning techniques used in this work include structural magnetic resonance imaging (MRI) to study the size and shape of brain structures (including cutting edge new methods with 7 Tesla MRI scanning), functional magnetic resonance imaging (fMRI) to study how the parts of the brain function individually and as part of brain circuits, and diffusion tensor imaging (DTI) to study the connections between brain structures.
Specialized Terms: Adolescence; Bipolar Disorder; Brain; Depression; Suicide; Development; Diffusion Tensor Imaging; Emotion; Functional Magnetic Resonance Imaging; Magnetic Resonance Imaging; Mania; Manic Depressive Disorder; Neuropsychiatry; Neuroscience; Women
Extensive Research Description
Dr. Blumberg is the Director of The Yale Mood Disorders Research Program (MDRP). The MDRP is dedicated to understanding the science of mood disorders, including bipolar disorder (manic-depressive illness) and depression. The MDRP brings together a multi-disciplinary group of scientists from across the Yale campus in a highly collaborative research effort. The scientists use a wide variety of scientific methods to study how genetic and environmental factors affect the brain and influence the expression of mood disorders across the lifespan. Goals of the MDRP include the identification of biological markers for mood and related disorders and discovery of new treatment strategies. It is hoped that these research efforts will lead to new and improved methods for early detection and treatment, and someday prevention, of mood disorders and suicide.
- MRI Brain Scanning Studies of Adolescents and Adults with Bipolar Disorder and Depression
- MRI Brain Scanning Studies of Healthy Adolescents and Adults
- MRI Brain Scanning Studies of Youths At-Risk for Bipolar Disorder
- MRI and Gene Studies of Genes and the Brain
- MRI Study of Stress Effects on the Brain
- MRI methods include: structural MRI, functional MRI, diffusion tensor imaging, and structural MRI and magnetic resonance imaging at 7 Tesla.
- Study of a non-medication psychobehavioral treatment "BE-SMART" to decrease symptoms of bipolar disorder and teach healthy skills to improve emotion regulation.
|Diseases of the Nervous System, Mental Health & Behavioral Research||Examination of Glutamate and mGluR5 in Psychiatric Disorders|
|Brain Response Associated With Parent-based Treatment for Childhood Anxiety Disorders|
|Diseases of the Nervous System, Genetics - Adult, Genetics - Pediatric, Mental Health & Behavioral Research||Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)|
|Mental Health & Behavioral Research||Imaging mGluR5 and synaptic density in psychiatric disorders|
|Aging, Diseases of the Nervous System||Glutathione and the aging brain|
|Children's Health, Mental Health & Behavioral Research||Ketamine Infusion for Adolescent Depression|
Longitudinal Diffusion Tensor Imaging Study of Adolescents and Young Adults With Bipolar Disorder.
Weathers J, Lippard ETC, Spencer L, Pittman B, Wang F, Blumberg HP. Longitudinal Diffusion Tensor Imaging Study of Adolescents and Young Adults With Bipolar Disorder. Journal Of The American Academy Of Child And Adolescent Psychiatry 2018, 57:111-117. 2018
Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder.
Johnston JA, Wang F, Liu J, Blond BN, Wallace A, Liu J, Spencer L, Cox Lippard ET, Purves KL, Landeros-Weisenberger A, Hermes E, Pittman B, Zhang S, King R, Martin A, Oquendo MA, Blumberg HP. Multimodal Neuroimaging of Frontolimbic Structure and Function Associated With Suicide Attempts in Adolescents and Young Adults With Bipolar Disorder. The American Journal Of Psychiatry 2017, 174:667-675. 2017
Effects of ANK3 variation on gray and white matter in bipolar disorder.
Lippard ET, Jensen KP, Wang F, Johnston JA, Spencer L, Pittman B, Gelernter J, Blumberg HP. Effects of ANK3 variation on gray and white matter in bipolar disorder. Molecular Psychiatry 2017, 22:1345-1351. 2017
Anterior Cortical Development During Adolescence in Bipolar Disorder.
Najt P, Wang F, Spencer L, Johnston JA, Cox Lippard ET, Pittman BP, Lacadie C, Staib LH, Papademetris X, Blumberg HP. Anterior Cortical Development During Adolescence in Bipolar Disorder. Biological Psychiatry 2016, 79:303-10. 2016
Corticostriatal-limbic gray matter morphology in adolescents with self-reported exposure to childhood maltreatment.
Edmiston EE, Wang F, Mazure CM, Guiney J, Sinha R, Mayes LC, Blumberg HP. Corticostriatal-limbic gray matter morphology in adolescents with self-reported exposure to childhood maltreatment. Archives Of Pediatrics & Adolescent Medicine 2011, 165:1069-77. 2011
Olfactocentric paralimbic cortex morphology in adolescents with bipolar disorder.
Wang F, Kalmar JH, Womer FY, Edmiston EE, Chepenik LG, Chen R, Spencer L, Blumberg HP. Olfactocentric paralimbic cortex morphology in adolescents with bipolar disorder. Brain : A Journal Of Neurology 2011, 134:2005-12. 2011
Functional and structural connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder.
Wang F, Kalmar JH, He Y, Jackowski M, Chepenik LG, Edmiston EE, Tie K, Gong G, Shah MP, Jones M, Uderman J, Constable RT, Blumberg HP. Functional and structural connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder. Biological Psychiatry 2009, 66:516-21. 2009
Age, rapid-cycling, and pharmacotherapy effects on ventral prefrontal cortex in bipolar disorder: a cross-sectional study
Blumberg, H.P., J.H. Krystal, R. Bansal, A. Martin, J. Dziura, K. Durkin, L. Martin, E. Gerard, D.S. Charney, B.S. Peterson. Biological Psychiatry. 2006, 59:611-618. 2006
Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder.
Blumberg HP, Kaufman J, Martin A, Whiteman R, Zhang JH, Gore JC, Charney DS, Krystal JH, Peterson BS. Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Archives Of General Psychiatry 2003, 60:1201-8. 2003
A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices.
Blumberg HP, Leung HC, Skudlarski P, Lacadie CM, Fredericks CA, Harris BC, Charney DS, Gore JC, Krystal JH, Peterson BS. A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Archives Of General Psychiatry 2003, 60:601-9. 2003
Rostral and orbital prefrontal dysfunction in the manic state of bipolar disorder
Blumberg, H.P., E. Stern, S. Ricketts, D. Martinez, J. de Asis, T. White, J. Epstein, N. Isenberg, P.A. McBride, I. Kemperman, S. Emmerich, V. Dhawan, D. Eidelberg, J.H. Kocsis, D.A. Silbersweig. American Journal of Psychiatry. 1999, 156:1986-1988. 1999