George Aghajanian, MD

Professor Emeritus of Psychiatry

Research Departments & Organizations

Psychiatry: Connecticut Mental Health Center | Neuroscience Research Training Program (NRTP)

Research Interests

Hallucinogens; Neuropharmacology; Neurophysiology; Psychiatry

Research Summary

In my laboratory we study mechanisms of chemical neurotransmission in the central nervous system using electrophysiological approaches in the rat brain slice preparation. Neurotransmission involves the release of transmitter substances from presynaptic elements onto postsynaptic neurons. The interaction of a neurotransmitter with a postsynaptic receptor then induces either a direct change in ionic conductance (Ligand-gated channel) or an indirect change in ionic conductance through a intermediary transducer molecule called a G protein (G-protein gated channel).

We study both kinds of neurotransmitter actions using intracellular and patch clamp recording from single neurons in brain slices. In addition we examine the ways in which psychotropic drugs modify the actions of neurotransmitters. Some of the drugs we are studying include: antipsychotics, antidepressants, hallucinogens, and opiates.

Specialized terms: Neurotransmission; antipsychotics; antidepressants; hallucinogens; opiates

Selected Publications

See list of PubMed publications

Edit this profile


Rong-Jian Liu

Contact Info

George Aghajanian, MD
Mailing Address
34 Park St.

New Haven, CT 06508-