Frank Giordano, MD

Associate Professor of Medicine (Cardiology)

Research Departments & Organizations

Internal Medicine: Cardiovascular Medicine

Molecular Virology

NHLBI Proteomics

Vascular Biology and Therapeutics Program

Office of Cooperative Research

Research Interests

Cardiology; Myocardial Ischemia; Receptors, Vascular Endothelial Growth Factor

Research Summary

Dr. Frank Giordano has been studying myocardial angiogenesis, evaluating the consequences of deletion or over-expression of pro-angiogenic genes in animal models. He has been working on the development of new viral vectors for gene delivery, in ongoing assessments of cardiovascular gene therapy. Dr. Giordano is leading the efforts to develop a viral vector core at Yale. Dr. Kerry Russell studies signaling pathways induced by growth factors of the neuregulin family, and their erbB receptors, and the effect of activation on vascular form and function.

Specialized Terms: Myocardial angiogenesis; Viral vectors

Activities

  • Cardiovascular Research United Kingdom (2011)

    Yale-Cambridge Program in Cardiovascular Research that focuses on arteriosclerosis, angiogenisis, vascular injury, and transplantation.

Selected Publications

  • Intracoronary administration of recombinant human vascular endothelial growth factor to patients with coronary artery disease.

    Henry TD, Rocha-Singh K, Isner JM, Kereiakes DJ, Giordano FJ, Simons M, Losordo DW, Hendel RC, Bonow RO, Eppler SM, Zioncheck TF, Holmgren EB, McCluskey ER. Intracoronary administration of recombinant human vascular endothelial growth factor to patients with coronary artery disease. American Heart Journal 2001, 142:872-80. 2001

  • Blood pressure changes and pharmacokinetics following vascular endothelial growth factor (rhVEGF) infusion in humans (In preparation).

    Eppler SM, McCluskey ER, Bloedow DC, Henry TD, Simons M, Giordano FJ, Zioncheck TF. Blood pressure changes and pharmacokinetics following vascular endothelial growth factor (rhVEGF) infusion in humans (In preparation). 2008

  • INK4B gene expression induces apoptosis in vascular smooth muscle cells and morphometric changes in cardiac myocytes and skeletal myoblasts (In preparation)

    Giordano FJ, Katragadda R, Rothman A, Lu C-Y: INK4B gene expression induces apoptosis in vascular smooth muscle cells and morphometric changes in cardiac myocytes and skeletal myoblasts (In preparation).

  • Infusion of VEGF by Intracoronary or Intravenous Route Ameliorates Ischemia Induced Contractile Abnormalities in the Pig (In preparation).

    Giordano FJ, Ross Jr J, Peterson KL, Dalton N, McCluskey T, Zionchek T, McKirnan MD: Infusion of VEGF by Intracoronary or Intravenous Route Ameliorates Ischemia Induced Contractile Abnormalities in the Pig (In preparation).

  • Intravenous administration of recombinant human vascular endothelial growth factor (rhVEGF) in patients with ischemic heart disease (In preparation).

    Simons M, Giordano FJ, Henry TD, Powell JS, Azrin MA, Kereiakes DJ, Annex B, Miller JM, Gibson CM, Lewin HC, Berman DS, McCluskey ER: Intravenous administration of recombinant human vascular endothelial growth factor (rhVEGF) in patients with ischemic heart disease (In preparation).

  • A Remote Role for Renalase.

    Giordano FJ, Wang Y, Desir GV. A Remote Role for Renalase. EBioMedicine 2016, 9:27-28. 2016

See list of PubMed publications

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Contact Info

Frank Giordano, MD
Mailing Address
Cardiovascular MedicinePO Box 208056
333 Cedar Street

New Haven, CT 06520-8056