Francis Lee, MD, PhD, FAAOS, MBA

Wayne O. Southwick Professor of Orthopaedics and Rehabilitation; Professor, Graduate School of Arts and Sciences; with Tenure in Traditional Track; Professor in Department of Pathology, Secondary Appointment; Biological and Biomedical Science Program, YSM Postgraduate School; Wayne O. Southwick Endowed Professor in Orthopedics and Rehabilitation

Research Departments & Organizations

Orthopaedics & Rehabilitation

Pathology

Yale Cancer Center: Signal Transduction

Research Interests

Bone and Bones; Bone Diseases, Infectious; Bone Marrow; Fracture Fixation; Musculoskeletal Diseases; Oncology Service, Hospital; Orthopedics; Osteoarthritis; Osteoblasts; Osteoclasts; Stem Cells; Tissue Engineering

Research Summary

Translational Musculoskeletal Research Programs (Tompkin 5 Orthopedic Translational Research Laboratory; Research Programs are supported by NIH andother research funding.)

  • Bone Inflammation: Biomaterials-Bone Interface Biology: Bio-implant related inflammation
  • Breast Cancer-Bone Interactions: Cancer-induced bone loss, Molecular imaging
  • Bone-Bacteria Interactions: Enhanced control of bone infection, Bone implant infection
  • Osteoclastogenesis; Novel regulators of osteoclastogenesis
  • Stem Cell, Tissue Engineering, Fracture Healing, and Tendon Regeneration
  • Fracture Healing
  • Bone Resorption
  • Orthopedic Translational Research
  • Sarcoma
  • Bone Metastasis
  • Orthobiologics
  • Orthopedics

Grants:

  • ERK Signaling in Inflammatory Bone Loss, NIH/NIAMS R01, PI: Francis Lee
  • Modification of Bone Grafts for Orthopaedic Procedures, NIH/NIAMS R01, PI: Francis Lee
  • Bone and Breast Cancer Molecular Interactions, NIH/NCI R01, PI: Francis Lee
  • Mechanobiological mechanism for inflammatory bone loss, NIH/NIBIB R01, PI: Francis Lee
  • Bio-Logical Modification of Structural Bone Allografts, Musculoskeletal Transplant Foundation, PI: Francis Lee
  • Inflammation in Rotator Cuff Tear and Repair, NIH/NIAMS K08, PI: David Kovacevic, Mentor: Francis Lee

Extensive Research Description

Please refer to NIH RePorter on Descriptions of NIH-funded Research Programs.

My research group is committed to engaging undergraduate students, Yale medical students for Thesis, M.D.-Ph.D. Students, other graduate students, and visiting fellows for research opportunities and career advancement. For inquires, please contact Alec.Pollak@yale.edu. I am an Orthopaedic Surgeon in active clinical practice and a Scientist fostering research experience for future clinician scholars and clinically relevant translational research scientists. I focus on high impact orthopaedic research that is directly relevant to pathogenesis, diagnosis, and treatment of Orthopaedic disorders.

Activities

  • Speaker, Faculty, Moderator Las Vegas, United States (2019)

    American Academy of Orthopaedic Surgeons Tumor Session Moderator; Presentation of 2 Papers; Metastatic Cancer Symposium Moderator, Organizer, Speaker

  • Key Note Speaker Farmington, United States (2019)

    U Conn Musculoskeletal Institute Research Day

  • Visiting Professor, University of California San Francisco San Francisco, United States (2018)

    Grand Round

  • AAOS/OREF/ORS Clinician Scholar Program Rosemont, United States (2017)

    AAOS/OREF/ORS Clinician Scholar Program

  • Lecture Seoul, South Korea (2017)

    Musculoskeletal Infection

  • Musculoskeletal Tumor Society Denver, United States (2017)

    Precision Medicine Prediction Of Skeletal Metastasis: Big Clinical And Gene Profiling Data Analysis

  • Musculoskeletal Tumor Society Denver, United States (2017)

  • Metastatic Breast Cancer Cells Destroy Bone by Inhibiting Ossification and Promoting Osteolytic Cytokine Production: A New Mechanism Kanazawa, Japan (2017 - 2017)

  • Intracellular Staphylococcus Aureus Are Resistant to Antibiotics San Diego, United States (2017 - 2017)

  • Mechanical Integrity of Unseeded, BMP-2 And Canine BMSC Seeded HA-PCL Scaffolds Compared to Allografts in Critical Size Defects in a Canine Model San Diego, United States (2017 - 2017)

  • Osteosarcoma Compartment Stiffness Affects Growth Rate San Diego, United States (2017 - 2017)

  • Trametinib Protects Bone from MRSA Induced Bone Erosion San Diego, United States (2017 - 2017)

  • Aggressive osteolytic breast cancer cells destroy bone by stealing calcium and making osteolytic cytokines: new mechanism and therapeutic target San Diego, United States (2017 - 2017)

  • Local PTH treatment enhances intercalary allograft incorporation San Diego, United States (2017 - 2017)

  • The Hidden Enemy: MRSA-Osteoblast Interaction and Its Consequences in Tissue Destruction and Recurrence Orlando, United States (2016 - 2016)

  • Erk Mediates Aggressive Growth And Bone Destruction In Osteolytic Metastatic Breast Cancers To Bone Orlando, United States (2016 - 2016)

Selected Publications

  • Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.

    Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, Levin D, Schwartz MG, Uygur A, Hayakawa Y, Gross S, Renz BW, Setlik W, Martinez AN, Chen X, Nizami S, Lee HG, Kang HP, Caldwell JM, Asfaha S, Westphalen CB, Graham T, Jin G, Nagar K, Wang H, Kheirbek MA, Kolhe A, Carpenter J, Glaire M, Nair A, Renders S, Manieri N, Muthupalani S, Fox JG, Reichert M, Giraud AS, Schwabe RF, Pradere JP, Walton K, Prakash A, Gumucio D, Rustgi AK, Stappenbeck TS, Friedman RA, Gershon MD, Sims P, Grikscheit T, Lee FY, Karsenty G, Mukherjee S, Wang TC. Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential. Cell 2015, 160:269-84. 2015

  • 3D printing for regenerative medicine: From bench to bedside.

    Juan Li, Ling He, Chen Zhou, Yue Zhou, Hanying Bai, Francis Y. Lee, Jeremy Mao. Materials Research Society Bulletin, 2015 Feb, Vol. 40: 145-154. 2015

  • Harnessing endogenous stem/progenitor cells for tendon regeneration.

    Lee CH, Lee FY, Tarafder S, Kao K, Jun Y, Yang G, Mao JJ. Harnessing endogenous stem/progenitor cells for tendon regeneration. The Journal Of Clinical Investigation 2015, 125:2690-701. 2015

  • Activation of Protein Kinase A in Mature Osteoblasts Promotes a Major Bone Anabolic Response.

    Tascau L, Gardner T, Anan H, Yongpravat C, Cardozo CP, Bauman WA, Lee FY, Oh DS, Tawfeek HA. Activation of Protein Kinase A in Mature Osteoblasts Promotes a Major Bone Anabolic Response. Endocrinology 2016, 157:112-26. 2016

  • Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones.

    Vorys GC, Bai H, Chandhanayingyong C, Lee CH, Compton JT, Caldwell JM, Gardner TR, Mao JJ, Lee FY. Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones. Clinical Biomechanics (Bristol, Avon) 2015, 30:1114-8. 2015

  • Tendon stem/progenitor cells regulate inflammation in tendon healing via JNK and STAT3 signaling.

    Tarafder S, Chen E, Jun Y, Kao K, Sim KH, Back J, Lee FY, Lee CH. Tendon stem/progenitor cells regulate inflammation in tendon healing via JNK and STAT3 signaling. FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology 2017, 31:3991-3998. 2017

  • Additive manufacturing of hydrogel-based materials for next-generation implantable medical devices.

    Sau Yin Chin, Yukkee Cheung Poh, Anne-Céline Kohler, Jocelyn T. Compton, Lauren L. Hsu, Kathryn M. Lau, Sohyun Kim, Benjamin W. Lee, Francis Y. Lee, Samuel K. Science Robotics. 04 Jan 2017: Vol. 2, Issue 2, eaah645. 2017

  • Calreticulin inhibits inflammation-induced osteoclastogenesis and bone resorption.

    Fischer CR, Mikami M, Minematsu H, Nizami S, Goo Lee H, Stamer D, Patel N, Yu Soung D, Back JH, Song L, Drissi H, Lee FY. Calreticulin inhibits inflammation-induced osteoclastogenesis and bone resorption. Journal Of Orthopaedic Research : Official Publication Of The Orthopaedic Research Society 2017, 35:2658-2666. 2017

  • Tissue engineering advances in spine surgery.

    Makhni MC, Caldwell JM, Saifi C, Fischer CR, Lehman RA, Lenke LG, Lee FY. Tissue engineering advances in spine surgery. Regenerative Medicine 2016, 11:211-22. 2016

  • Whole grape alleviates inflammatory arthritis through inhibition of tumor necrosis factor.

    Journal of Functional Foods, Volume 35: 458-465, 2017 2017

See list of PubMed publications

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Coauthors

JungHo Back

Contact Info

Francis Lee, MD, PhD, FAAOS, MBA
Mailing Address
Orthopaedics & Rehabilitation47 College Street Second Floor
New Haven, CT 06520
Cancer-Induced Bone Loss