Faye Rogers, PhD

Associate Professor of Therapeutic Radiology

Research Departments & Organizations

Therapeutic Radiology: Radiobiology


Yale Cancer Center: Radiobiology & Radiotherapy

Office of Cooperative Research

Research Interests

Apoptosis; Biochemistry; Breast Neoplasms; DNA Repair; Drug Design; Genomic Instability; Nucleic Acids; Radiation Oncology

Research Summary

Overexpression of HER2, which occurs in ~30% of human breast cancers, correlates with enhanced tumor aggressiveness and decreased patient survival. Although Herceptin has significantly improved the treatment of HER2-positive tumors, drug resistance remains an obstacle in a high fraction of patients. The ability to target these cancers using antitumor agents with mechanisms of action that are independent of HER2 cellular growth function, represents a powerful tool to circumvent this form of resistance. Our lab is interested in the design of novel gene-targeted molecules that can be used in the treatment of both HER2-positive and Hercetin-resistant breast cancers.

Specialized Terms: Breast cancer; Drug design; Altered helical structures; Cancer and genomic instability; DNA repair and apoptosis

Selected Publications

See list of PubMed publications

Edit this profile