D. S. Fahmeed Hyder, PhD

Professor of Radiology and Biomedical Imaging and of Biomedical Engineering; Technical Director, Magnetic Resonance Research Center (mrrc.yale.edu); Program Director, Core Center for Quantitative Neuroscience with Magnetic Resonance (qnmr.yale.edu)

Research Departments & Organizations

Radiology & Biomedical Imaging: Bioimaging Sciences: Magnetic Resonance Research Center; Magnetic Resonance Spectroscopy

Diabetes Research Center

Interdepartmental Neuroscience Program

Yale Cancer Center: Radiobiology & Radiotherapy

Office of Cooperative Research

Research Interests

Biomedical Engineering; Magnetic Resonance Imaging; Molecular Probes; Neoplasms by Histologic Type; Neurosciences; Radiology

Research Summary

Dr. Hyder uses magnetic resonance (MR) methods to map physiology and chemistry that underlies brain function, for early disease detection but also for targeted drug delivery and monitoring treatments. MR imaging (MRI) is attractive because of its non-invasive and 3D nature to capture anatomical and functional information. The brain has high-energy demands to support its neural infrastructure and functional connections, but how much energy supports anatomical vs. functional needs is unknown. Pathways by which neural cells use nutrients to fuel their growth vs. function are measured by MR spectroscopy (MRS). Among his contributions are high-resolution functional MRI (fMRI) developments, but with calibrated fMRI for imaging energy demanded by activities at the neuropil. Another area is a new class of paramagnetic MRS agents that can map pH and other physicochemical parameters important in cancer. These breakthroughs provide insights into the brain at work, from synapse to networks, in health and disease.

Speciailzed Terms: Brain energy metabolism; Neurovascular and neurometabolic coupling; BOLD technology; BIRDS technology; Calibrated fMRI technology; SAR technology; Cancer imaging and therapy technology; Molecular probes and nanocarriers

Extensive Research Description

Specific areas of interest in functional imaging include (i) understanding the role of the extraordinarily high energy demands of ongoing and intrinsic activity within neural populations as potential for quantitative disease biomarker, (ii) advancing the spatiotemporal resolution of functional imaging to understand the relation of cellular metabolism in health and disease (e.g., healthy aging, Alzheimer’s disease, depression, epilepsy, schizophrenia), and (iii) developing advanced calibrated fMRI methods for using oxidative energy as an absolute index of neural activity, both with task and rest paradigms, across cortical and subcortical regions.

For molecular imaging we use a method called BIRDS, which we developed and quite unconventionally detects the paramagnetically-shifted and non-exchangeable protons from lanthanide (or transition) metal ion probes for high spatiotemporal resolution biosensing. Highly precise molecular imaging of temperature and pH is achievable with BIRDS. Current areas of relevance are (i) design of new molecular probes for BIRDS, (ii) early cancer detection and metastasis using absolute pH imaging, (iii) application of new probes for BIRDS as molecular targets for diseases (e.g., diabetes), and (iv) detection of tumor response to treatments (e.g., radiation, chemotherapy, heat).

Calibrated fMRI for basal metabolism – simulation studies to assess sensitivities required for fMRI and perfusion data to extract basal metabolism from calibrated fMRI data

Quantitative metabolic PET – analysis of whole brain PET data of glucose and oxidative metabolism in the human brain in relation to blood flow

Liposomal BIRDS – development and/or characterization of newly developed probes encapsulated inside liposomes for BIRDS

Dendrimeric BIRDS – development and/or characterization of newly developed macromolecular-based probes for BIRDS

Clinical Trials

Conditions Study Title
Mental Health & Behavioral Research Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response

Activities

  • Imaging and NMR Studies of Brain Metabolism Miami, United States (2012)

    Professor Hyder collaborates with Professor Jorge Riera of Florida International University, Miami, Florida. These collaborations focus on imaging and NMR studies of brain metabolism in health and disease.

  • High Resolution PET Imaging of Human Brain Copenhagen, Denmark (2012)

    Professor Hyder collaborates with Professor Albert Gjedde of University of Copenhagen, Copenhagen, Denmark. These collaborations focus on imaging of brain metabolism in health humans with PET technology.

  • High resolution of PET Imaging of Anesthesia in Human Brain Irvine, United States (2012)

    Professor Hyder collaborates with Professor Michael Alkire of University of California, Irvine, California. These collaborations focus on imaging of brain metabolism under anesthesia in health humans with PET technology.

  • Brain Regional Temperature Changes Wuppertal, Germany (2008)

    Professor Hyder collaborates with Hubert Trubel of Bayer Health Care AG, Wuppertal, Germany. The collaborations focus on temperature changes and oxygen efflux in the brain.

  • fMRI Studies During non-Chemically Based Hypotension Budapest, Hungary (2008)

    Professor Hyder participates in collaborative research with Professor Andras Eke of the Institute of Human Physiology and Clinical Experimental Research at Semmelweis University in Budapest, Hungary. Research focuses on fMRI studies.

  • Chair, Education Committee, International Society for Cerebral Blood Flow and Metabolism (2007 - 2009)

    Chair, Education Committee, International Society for Cerebral Blood Flow and Metabolism

  • Odor Stimuli in Olfactory Bulb Wuhan, China (2007)

    Professor Hyder participates in collaborative research with Professor Fuqiang Xu of the Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China. These collaborations focus on the assessment and discrimination of odor stimuli by dynamic fMRI.

  • Board of Directors, International Society for Cerebral Blood Flow and Metabolism (2005 - 2009)

    Board of Directors, International Society for Cerebral Blood Flow and Metabolism

  • Executive Committee, International Society on Oxygen Transport to Tissue (2005 - 2010)

    Executive Committee, International Society on Oxygen Transport to Tissue

Selected Publications

See list of PubMed publications

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