Emanuela Bruscia, PhD

Associate Professor of Pediatrics (Respiratory)

Research Departments & Organizations

Pediatrics: Pediatric Pulmonology, Allergy, Immunology & Sleep Medicine

CPIRT - Pulmonary Infection Research and Treatment

Office of Cooperative Research

Research Interests

Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Lung; Macrophages; Pediatrics; Respiration Disorders

Research Summary

Our research aims to understand how CFTR--the gene that, when mutated, causes Cystic Fibrosis (CF)--affects innate immunity and how this will impact the progression of CF lung disease. We have performed pioneering studies demonstrating that CFTR expression is necessary for the normal function of an important player of the innate immune response: macrophages. Using in vitro and in vivo models, we are dissecting the molecular mechanisms by which CFTR affects these cells.

Specialized Terms: Cystic Fibrosis; Lung inflammation; Macrophages

Selected Publications

See list of PubMed publications

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