Elijah Paintsil

Associate Professor of Pediatrics (Infectious Disease), of Epidemiology (Microbial Diseases) and of Pharmacology; Associate Professor of Pharmacology

Research Departments & Organizations

Pediatrics: Pediatric Infectious Diseases

School of Public Health: Center for Interdisciplinary Research on AIDS | Epidemiology of Microbial Diseases

Virology Laboratories

Yale Cancer Center: Virus and Other Infection-associated Cancers

Yale Institute for Global Health

Global Health Studies

MacMillan Center: African Studies

Office of Cooperative Research

Research Interests

Brazil; Ghana; Hepatitis C; HIV; HIV Reverse Transcriptase; Infectious Disease Medicine; Molecular Epidemiology; Pediatrics; Pharmacology

Research Summary

Research focus is on

  1. The disposition of anti-HIV drugs, e.g. nucleoside analogs such as AZT, in HIV-infected individuals in relation to treatment response, drug toxicity, and evolution of drug resistance
  2. Understanding of the dynamics of hepatitis C virus (HCV) and HIV transmission

Specialized Terms: HIV translational research; Cellular pharmacology of HIV-RT inhibitors in relation to clinical toxicities; Fitness and evolution of HIV drug resistant mutants; Molecular epidemiology and dynamics of HIV/HCV transmission

Extensive Research Description

  1. Viability of HCV in Syringes using a Novel Microculture System This study examines how long Hepatitis C virus survives in syringes at different storage conditions.
  2. HIV Nucleoside Analogs Translational Studies: Resistance and Metabolism This study will examine individual differences in intracellular concentration of nucleoside analogs in relation to toxicity and resistance evolution.
  3. Biomarkers for monitoring Pediatric HIV therapy and disease progression in resource limited setting.

Activities

  • Infectious Diseases Research Sao Paulo, Brazil (2009)

    Capacity building

  • 1. Studying the effect of malaria during pregnancy on mother-to-child-transmission of HIV. 2) Surrogate biomarkers for monitoring HIV therapy and disease progression of Pediatric HIV in resource limited setting Accra, Ghana (2006)

    Yale-Ghana Partnership in Global Infectious Diseases Research with the mission of accelerating progress in Infectious Diseases and Public Health research in Africa through collaborative partnerships that effectively build intrinsic research capacity, reverse “brain-drain” by strengthening academic...

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