Eda Cengiz, MD, MHS, FAAP

Associate Professor of Pediatrics (Endocrinology)

Research Departments & Organizations

Pediatrics: Pediatric Endocrinology & Diabetes: Diabetes Program

Diabetes Research Center

Office of Cooperative Research

Research Interests

Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Angiopathies

Research Summary

  • Pharmacokinetics & pharmacodynamics of insulin therapy;
  • Artificial Pancreas Project (APP);
  • Preservation of beta cells for children with new onset type 1 diabetes;
  • Type 1 Diabetes Exchnage and Pediatric Diabetes Consortium (PDC) project: building a database to monitor diabetes management and complications;
  • Integrating technology with diabetes care: use of new high-tech devices and methods to improve insulin delivery and function;
  • Detecting early cardiovascular disease markers for children and adolescents with type 1 diabetes.

Extensive Research Description

  • Closed loop insulin delivery system
  • Clamp studies to demonstrate pharmacokinetics and pharmacodynamics of insulin
  • Detecting early cardiovascular disease markers for children with type 1 diabetes including peripheral arterial tonometry
  • Pediatric Diabetes Consortium:utilizing a database registry to assess treatment approaches for children and youth with new-onset type 1 diabetes
  • Anti -CD3 treatment for preservation of beta cells in children with new onset type 1 diabetes
  • Artificial pancreas project
  • PKPD of insulin therapy
  • Pediatric Diabetes Consortium
  • Glucose sensor studies
  • Effect of the Human Recombinant Hyaluronidase (rHuPH20) on the Pharmacokinetic & Pharmacodynamic (PK/PD) Properties of Lispro and Aspart Insulin using the Euglycemic Clamp and on Meal-related Glucose Excursions during Open- and Closed-loop Insulin Delivery.

Clinical Trials

Conditions Study Title
Children's Health Trial to Confirm the Efficacy and Safety of Dasiglucagon in the Treatment of Hypoglycemia in T1DM Children
Children's Health, Diabetes Mellitus - Type 1, Diseases of the Endocrine System Day and Night Closed-loop in Young People With Type 1 Diabetes (DAN05)
Children's Health, Diabetes Mellitus - Type 1, Diseases of the Endocrine System Yale-Harvard Hotel-based Closed-Loop Studies in Children
Children's Health, Diabetes Mellitus - Type 1 Evaluation of the Dreamed Advisor Pro for Automated Insulin Pump Setting Adjustments in Children and Adolescents With Type 1 Diabetes- The Advice4U Pro Study (Advice4U)
Diseases of the Blood Improving Post-Prandial Blood Glucose Control With Afrezza During Closed-Loop Therapy
Diabetes Mellitus - Type 1, Diseases of the Endocrine System, Diseases of the Nervous System Impact of Hypoglycemia on Brain Ketone and Neurotransmitter Metabolism in Type 1 DM
Diabetes Mellitus - Type 1, Diseases of the Endocrine System Insulet Artificial Pancreas Free-Living IDE3
Children's Health, Diseases of the Endocrine System, Immune System, Women's Health Blood Glucose Variability and Insulin Action During Menstrual Cycle in Females With Type 1 Diabetes

Activities

  • Early Cardiovascular Disease Markers for Children with Type 1 Diabetes Jerusalem, Israel (2009 - 2012)

    This prospectively designed clinical study investigates signs of early cardiovascular disease in children with type 1 diabetes in the US and in Israel.

Selected Publications

See list of PubMed publications

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Contact Info

Eda Cengiz, MD, MHS, FAAP
Mailing Address
Pediatric Endocrinology & DiabetesPO Box 208064
New Haven, CT 06520-8064

Curriculum Vitae