Eda Cengiz, MD, MHS, FAAP

Associate Professor of Pediatrics (Endocrinology)

Research Departments & Organizations

Pediatrics: Pediatric Endocrinology & Diabetes: Diabetes Program

Diabetes Research Center

Office of Cooperative Research

Research Interests

Diabetes Complications; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Angiopathies

Research Summary

  • Pharmacokinetics & pharmacodynamics of insulin therapy;
  • Artificial Pancreas Project (APP);
  • Preservation of beta cells for children with new onset type 1 diabetes;
  • Type 1 Diabetes Exchnage and Pediatric Diabetes Consortium (PDC) project: building a database to monitor diabetes management and complications;
  • Integrating technology with diabetes care: use of new high-tech devices and methods to improve insulin delivery and function;
  • Detecting early cardiovascular disease markers for children and adolescents with type 1 diabetes.

Extensive Research Description

  • Closed loop insulin delivery system
  • Clamp studies to demonstrate pharmacokinetics and pharmacodynamics of insulin
  • Detecting early cardiovascular disease markers for children with type 1 diabetes including peripheral arterial tonometry
  • Pediatric Diabetes Consortium:utilizing a database registry to assess treatment approaches for children and youth with new-onset type 1 diabetes
  • Anti -CD3 treatment for preservation of beta cells in children with new onset type 1 diabetes
  • Artificial pancreas project
  • PKPD of insulin therapy
  • Pediatric Diabetes Consortium
  • Glucose sensor studies
  • Effect of the Human Recombinant Hyaluronidase (rHuPH20) on the Pharmacokinetic & Pharmacodynamic (PK/PD) Properties of Lispro and Aspart Insulin using the Euglycemic Clamp and on Meal-related Glucose Excursions during Open- and Closed-loop Insulin Delivery.

Clinical Trials

Conditions Study Title
Diabetes Mellitus - Type 1 Fuzzy Logic Automated Insulin Regulation (FLAIR)
Children's Health Trial to Confirm the Efficacy and Safety of Dasiglucagon in the Treatment of Hypoglycemia in T1DM Children
Children's Health, Diabetes Mellitus - Type 1, Diseases of the Endocrine System Day and Night Closed-loop in Young People With Type 1 Diabetes (DAN05)
Children's Health, Diabetes Mellitus - Type 1, Diseases of the Endocrine System Yale-Harvard Hotel-based Closed-Loop Studies in Children
Diseases of the Blood Improving Post-Prandial Blood Glucose Control With Afrezza During Closed-Loop Therapy
Diabetes Mellitus - Type 1, Diseases of the Endocrine System, Diseases of the Nervous System Impact of Hypoglycemia on Brain Ketone and Neurotransmitter Metabolism in Type 1 DM
Diabetes Mellitus - Type 1, Diseases of the Endocrine System Insulet Artificial Pancreas Free-Living IDE3
Children's Health, Diseases of the Endocrine System, Immune System, Women's Health Blood Glucose Variability and Insulin Action During Menstrual Cycle in Females With Type 1 Diabetes

Activities

  • Early Cardiovascular Disease Markers for Children with Type 1 Diabetes Jerusalem, Israel (2009 - 2012)

    This prospectively designed clinical study investigates signs of early cardiovascular disease in children with type 1 diabetes in the US and in Israel.

Selected Publications

See list of PubMed publications

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Contact Info

Eda Cengiz, MD, MHS, FAAP
Mailing Address
Pediatric Endocrinology & DiabetesPO Box 208064
New Haven, CT 06520-8064

Curriculum Vitae