Don Nguyen, PhD

Associate Professor of Pathology

Research Departments & Organizations

Pathology: Nguyen Lab | Pathology Research

Medical Oncology

Yale Cancer Center: Signal Transduction

Yale Stem Cell Center

Research Interests

Genomics; Inflammation; Lung Neoplasms; Neoplasm Metastasis; Neoplasm Micrometastasis; Pathology

Research Summary

Cancer metastasis remains an unresolved clinical and biological problem. This is particularly relevant in the case of thoracic malignancies, which can spread aggressively to distant organs with limited opportunity for effective therapeutic intervention. Metastatic lung cancer cells are believed to acquire complex biological properties by deregulating pleiotoropic genetic programs and interacting with their microenvironment. My laboratory is interested in uncovering the molecular, cellular, and physiological determinants of metastasis by different lung cancer subtypes. Lung cancers most notably metastasize to the central nervous system. We are therefore also studying how the unique brain microenvironment alters the therapeutic response of disseminated tumor cells.  In our endeavors, we utilize a variety of approaches such as animal modeling, functional genomics, cell biology, bioinformatics, and clinical validation.

Specialized Terms: Metastasis; Lung cancer; Cancer genomics; Tumor microenvironment; Brain metastasis

Clinical Trials

Conditions Study Title
Lung Determining Mechanisms of Sensitivity and Resistance to Anti-Cancer Therapy for Advanced Lung Cancer

Selected Publications

See list of PubMed publications

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Contact Info

Don Nguyen, PhD
Office Location
Department Of PathologyBrady Memorial Laboratory
310 Cedar Street, Ste BML 348B

New Haven, CT 06510
Mailing Address
Pathology310 Cedar Street
PO Box 208023

New Haven, CT 06520-8023

Nguyen lab website

Co-option of the brain microenvironment by metastatic lung cancer cells

Soon after lung cancer cells (in green) disseminate into the brain, they can utilize extracellular matrix molecules (in red) derived from resident stromal cells (white) to shield themselves from the hostile surroundings.