Research Departments & Organizations
Cancer metastasis remains an unresolved clinical and biological problem. This is particularly relevant in the case of thoracic malignancies, which can spread aggressively to distant organs with limited opportunity for effective therapeutic intervention. Metastatic lung cancer cells are believed to acquire complex biological properties by deregulating pleiotoropic genetic programs and interacting with their microenvironment. My laboratory is interested in uncovering the molecular, cellular, and physiological determinants of metastasis by different lung cancer subtypes. Lung cancers most notably metastasize to the central nervous system. We are therefore also studying how the unique brain microenvironment alters the therapeutic response of disseminated tumor cells. In our endeavors, we utilize a variety of approaches such as animal modeling, functional genomics, cell biology, bioinformatics, and clinical validation.
Specialized Terms: Metastasis; Lung cancer; Cancer genomics; Tumor microenvironment; Brain metastasis
|Lung||Determining Mechanisms of Sensitivity and Resistance to Anti-Cancer Therapy for Advanced Lung Cancer|
Extracellular Matrix Receptor Expression in Subtypes of Lung Adenocarcinoma Potentiates Outgrowth of Micrometastases.
Stevens LE, Cheung WK, Adua SJ, Arnal-Estapé A, Zhao M, Liu Z, Brewer K, Herbst RS, Nguyen DX. Extracellular Matrix Receptor Expression in Subtypes of Lung Adenocarcinoma Potentiates Outgrowth of Micrometastases. Cancer Research 2017, 77:1905-1917. 2017
Lineage factors and differentiation states in lung cancer progression.
Cheung W.K. and Nguyen D.X. (2015). Oncogene, 19;34(47):5771-80. 2015
Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis.
Cheung WK, Zhao M, Liu Z, Stevens LE, Cao PD, Fang JE, Westbrook TF, Nguyen DX. Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis. Cancer Cell 2013, 23:725-38. 2013
Tracing the origins of metastasis.
Nguyen DX. Tracing the origins of metastasis. The Journal Of Pathology 2011, 223:195-204. 2011
WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis.
Nguyen DX, Chiang AC, Zhang XH, Kim JY, Kris MG, Ladanyi M, Gerald WL, Massagué J. WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell 2009, 138:51-62. 2009
Genes that mediate breast cancer metastasis to the brain.
Bos PD, Zhang XH, Nadal C, Shu W, Gomis RR, Nguyen DX, Minn AJ, van de Vijver MJ, Gerald WL, Foekens JA, Massagué J. Genes that mediate breast cancer metastasis to the brain. Nature 2009, 459:1005-9. 2009