David Assis, MD

Assistant Professor of Medicine (Digestive Diseases)

Research Departments & Organizations

Internal Medicine: Digestive Diseases | Liver Center

Research Interests

Autoimmune Diseases; Cystic Fibrosis; Hepatitis; Liver; Liver Diseases

Research Summary

I am evaluating the role of an inflammatory protein called MIF in autoimmune hepatitis and its ability to be a predictor of disease severity, response to therapy, and a predictor of disease relapse.

I am evaluating mechanisms of disease and therapies for the treatment of Primary Sclerosing Cholangitis.

Extensive Research Description

I am investigating the role of macrophage migration inhibitory factor (MIF) in autoimmune hepatitis. Active studies involve serial measurement of serum MIF and its soluble receptor (CD74) in the blood of patients with autoimmune hepatitis, to evaluate if these proteins can serve as biomarkers of disease activity.

I am evaluating cellular mechanisms of the release of the CD74 protein and its neutralizing activity on the cytokine MIF.

I am investigating the role of MIF in the pathophysiology of autoimmune hepatitis in animal models of disease.

I am evaluating potential new therapies for Primary Sclerosing Cholangitis (PSC) including all-trans retinoic acid.

A study of the role of macrophage migration inhibitory factor (MIF) in autoimmune hepatitis, through clinical and translational investigations.

Clinical Trials

Conditions Study Title
Diseases of the Digestive System - Liver Seladelpar in Subjects With Primary Biliary Cholangitis (PBC) and an Inadequate Response to or an Intolerance to Ursodeoxycholic Acid (UDCA)
Diseases of the Digestive System - Liver 13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF (ALFSG-MBT)
Diseases of the Digestive System - Liver A 5-year Longitudinal Observational Study of Patients With Primary Biliary Cholangitis
Diseases of the Digestive System - Liver Mindfulness to treat fatigue in patients with PBC
Diseases of the Digestive System - Liver A POC and Dose-Ranging Study of HTD1801 in PSC Patients
Diseases of the Digestive System - Liver An Efficacy Trial of Low Dose All-trans Retinoic Acid in Patients With Primary Sclerosing Cholangitis
Hepatitis, HIV/AIDS, Immune System, Infectious Diseases Screening In Anticipation of Future Research

Selected Publications

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