Craig Roy, PhD

Waldemar Von Zedtwitz Professor of Microbial Pathogenesis and of Immunobiology; Vice-Chair, Department of Microbial Pathogenesis

Research Departments & Organizations

Microbial Pathogenesis


CPIRT - Pulmonary Infection Research and Treatment

Office of Cooperative Research

Research Interests

Bacteria; Coxiella burnetii; Immune System; Legionella pneumophila; Macrophages; Protozoan Proteins; Vesicular Transport Proteins

Research Summary

The focus of our research is to understand the molecular and cellular events that enable microbial pathogens to evade host defense mechanisms. In particular, we are interested in how bacteria that replicate inside mammalian cells create specialized vacuoles that support pathogen replication. We have been using Legionella pneumophila and Coxiella burnetii as model pathogens to study this process. We have been characterizing a type IV secretion system called Dot/Icm that delivers bacterial effector proteins into the eukaryotic host cell cytosol. The goals of this research are to determine the mechanism by which these bacterial effector proteins regulate phagosome maturation, modulate host immunity, and subvert eukaryotic cell functions.

Specialized Terms: Molecular; Cellular; Microbial pathogens; Bacteria; Vesicular transport; Legionella pneumophila; Coxiella burnetii; Macrophages; Protozoan; Proteins

Selected Publications

See list of PubMed publications

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Contact Info

Craig Roy, PhD
Mailing Address
Microbial PathogenesisDepartment of Microbial Pathogenesis
295 Congress Avenue, BCMM 354B

New Haven, CT 06536-0812