Christine Jacobs-Wagner, PhD

William H. Fleming, M.D. Professor of Molecular, Cellular, and Developmental Biology and of Microbial Pathogenesis; HHMI Investigator; Director of Microbial Sciences Institute

Research Departments & Organizations

Microbial Pathogenesis

Yale Microbial Sciences Institute

Research Interests

Bacteria

Research Summary

We study the molecular mechanisms underlying bacterial multiplication. Bacteria are renowned for their fast multiplication. During their short cell cycles, bacteria grow, replicate and segregate their chromosomes and divide. They do all of this with sometimes blazing speed and with remarkable temporal and spatial accuracy, which explains their success.

Despite the medical, agricultural and ecological importance of bacteria, little is known about the molecular mechanisms involved in growth, DNA segregation, cell division and cell morphogenesis. Similarly, the temporal and spatial mechanisms regulating these essential processes remain largely elusive. We address these fundamental questions using genetics, biochemistry, quantitative fluorescence microscopy and modeling.

Activities

  • Cell morphogenesis in Caulobacter crescentus Newcastle upon Tyne, United Kingdom (2004 - 2013)

    1. Investigation of how cytoskeletal elements affect cell wall morphogenesis in bacteria
    2. Analysis of peptidoglycan composition in C. crescentus

Selected Publications

See list of PubMed publications

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