Research Departments & Organizations
Arthritis, Rheumatoid; Autoimmune Diseases; Autoimmune Diseases of the Nervous System; Computational Biology; Demyelinating Autoimmune Diseases, CNS; Diabetes Mellitus, Type 1; Genetic Research; Genetics; Genetics, Medical; Genetics, Population; Genomics; Graves Disease; Human Genome Project; Immune System Diseases; Inflammatory Bowel Diseases; Lupus Erythematosus, Systemic; Multiple Sclerosis; Systems Biology; Thyroiditis, Autoimmune
We look for genetic factors that predispose to disease and try to understand the biology they perturb. We ask what genes are perturbed, what processes they participate in and whether these perturbations are sufficient to induce differences at the molecular and cellular levels.This gives us novel targets for biomarkers, diagnosis and treatment.
Our approach encompasses statistical and computational tools, genetics and molecular biology. We are a hybrid lab with strong quantitative and experimental skills and we cycle between hypotheses generated by rigorous analysis and confirmation and discovery in experimental systems.
Immune-mediated disease genetics: the shared basis of pathogenesis.
Cotsapas C, Hafler DA. Immune-mediated disease genetics: the shared basis of pathogenesis. Trends In Immunology 2013, 34:22-6. 2013
Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis.
Querol L, Clark PL, Bailey MA, Cotsapas C, Cross AH, Hafler DA, Kleinstein SH, Lee JY, Yaari G, Willis SN, O'Connor KC. Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis. Neurology 2013, 81:956-63. 2013