Research Departments & Organizations
Ischemic stroke is a leading cause of death with limited therapeutic options. Blood flow delivery to the area of a stroke is dependent upon many factors. Dr. Wira and stroke researchers with the Yale ED have participated in studies evaluating neuroprotective agents, clot dissolution medications, neuro-interventional procedures, and have also conducted observational studies characterizing the hemodynamic profile and myocardial complications seen in acute stroke patients. This research will lead to the development of better acute therapeutic interventions in ischemic stroke.
Specialized Terms: Stroke; Sepsis; Cardiac arrest
|Diseases of the Nervous System||Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction (CHARM)|
|Diseases of the Nervous System||An International Study to Evaluate Diagnostic Efficacy of Flurpiridaz (18F) Injection PET MPI in the Detection of Coronary Artery Disease (CAD)|
|Diseases of the Blood, Infectious Diseases||Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS)|
|Diseases of the Nervous System||Impact of Fever Prevention in Brain Injured Patients (INTREPID)|
Etomidate use for rapid sequence intubation is safe in patients with severe sepsis
Ehrman R, Wira, C, Mullen M, et al; Etomidate use for rapid sequence intubation is safe in patients with severe sepsis, Internal and Emergency Medicine, 2011 (in press). 2009
Cardiac complications in acute ischemic stroke.
Wira CR, Rivers E, Martinez-Capolino C, Silver B, Iyer G, Sherwin R, Lewandowski C. Cardiac complications in acute ischemic stroke. The Western Journal Of Emergency Medicine 2011, 12:414-20. 2011
Surviving sepsis in low-income and middle-income countries: new directions for care and research.
Becker JU, Theodosis C, Jacob ST, Wira CR, Groce NE. Surviving sepsis in low-income and middle-income countries: new directions for care and research. The Lancet. Infectious Diseases 2009, 9:577-82. 2009
Application of normothermic cardiac arrest algorithms to hypothermic cardiac arrest in a canine model.
Wira C, Martin G, Stoner J, Margolis K, Donnino M. Application of normothermic cardiac arrest algorithms to hypothermic cardiac arrest in a canine model. Resuscitation 2006, 69:509-16. 2006