Charles Wira, MD

Associate Professor Term; Liaison, Yale-New Haven Stroke Program

Research Departments & Organizations

Center for Neuroepidemiology and Clinical Neurological Research

Office of Cooperative Research

Research Interests

Emergency Medicine; Heart Arrest; Sepsis; Stroke

Research Summary

Ischemic stroke is a leading cause of death with limited therapeutic options. Blood flow delivery to the area of a stroke is dependent upon many factors. Dr. Wira and stroke researchers with the Yale ED have participated in studies evaluating neuroprotective agents, clot dissolution medications, neuro-interventional procedures, and have also conducted observational studies characterizing the hemodynamic profile and myocardial complications seen in acute stroke patients. This research will lead to the development of better acute therapeutic interventions in ischemic stroke.

Specialized Terms: Stroke; Sepsis; Cardiac arrest

Clinical Trials

Conditions Study Title
Diseases of the Nervous System Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction (CHARM)
Diseases of the Nervous System An International Study to Evaluate Diagnostic Efficacy of Flurpiridaz (18F) Injection PET MPI in the Detection of Coronary Artery Disease (CAD)
Diseases of the Blood, Infectious Diseases Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS)
Diseases of the Nervous System Impact of Fever Prevention in Brain Injured Patients (INTREPID)

Selected Publications

See list of PubMed publications

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