Charles Cha, MD, FACS

Associate Professor of Surgery (Oncology and Gastrointestinal)

Research Departments & Organizations

Surgery: Surgical Oncology

Liver Cancer Program

Yale Cancer Center: Developmental Therapeutics | Liver Cancer Program

Office of Cooperative Research

Research Interests

Colorectal Surgery; Esophageal Neoplasms; Gastroenterology; Liver Neoplasms; Medical Oncology

Research Summary

Dr. Cha has established an active research laboratory studying the effects of angiogenesis on colorectal and liver malignancy using gene-silencing techniques to silence angiogenic factors leading to decreased tumor growth. He collaborates with a number of Yale researchers to use nanoparticle delivery systems to target tumor cells before they can grow larger than a few millimeters in size. His laboratory effort has resulted in support from a number of funding sources including the Hartford Foundation, American College of Surgeons Faculty Research Award, Ohse Foundation, and the VA Healthcare System Career Development Award. His clinical research interests include the determination of the diagnostic and therapeutic utility of angiogenic inhibitors for treatment of colorectal and liver cancers. In addition, he is involved in clinical outcomes research in surgery for liver, gastric, esophageal and colorectal malignancy using the National Surgical Quality Improvement Program Database as well as the Connecticut Tumor Registry. In his lab, Dr. Cha has mentored a number of medical students, surgical residents, fellows and postdoctoral students including Steve Ward, MD, Abby Mulkeen, MD, Peter Yoo, MD, Sharon Kiang, MD, and Wenli Gao, PhD., leading to over 20 publications and honors such as Best Resident Paper at the New England Surgical Society (Mulkeen), Ohse Foundation Award (Mulkeen, Yoo), Pfizer/ACS Travel Scholarship (Yoo), Best Case Presentation Connecticut Chapter, ACS (Yoo), NIH LRP Award (Yoo).

Extensive Research Description

Dr. Cha has established an active research laboratory studying the effects of angiogenesis on colorectal and liver malignancy using gene-silencing techniques to silence angiogenic factors leading to decreased tumor growth. He collaborates with a number of Yale researchers to use nanoparticle delivery systems to target tumor cells before they can grow larger than a few millimeters in size. His laboratory effort has resulted in support from a number of funding sources including the Hartford Foundation, American College of Surgeons Faculty Research Award, Ohse Foundation, and the VA Healthcare System Career Development Award. His clinical research interests include the determination of the diagnostic and therapeutic utility of angiogenic inhibitors for treatment of colorectal and liver cancers. In addition, he is involved in clinical outcomes research in surgery for liver, gastric, esophageal and colorectal malignancy using the National Surgical Quality Improvement Program Database as well as the Connecticut Tumor Registry. In his lab, Dr. Cha has mentored a number of medical students, surgical residents, fellows and postdoctoral students including Steve Ward, MD, Abby Mulkeen, MD, Peter Yoo, MD, Sharon Kiang, MD, and Wenli Gao, PhD., leading to over 20 publications and honors such as Best Resident Paper at the New England Surgical Society (Mulkeen), Ohse Foundation Award (Mulkeen, Yoo), Pfizer/ACS Travel Scholarship (Yoo), Best Case Presentation Connecticut Chapter, ACS (Yoo), NIH LRP Award (Yoo).

Activities

  • Invited Presentation, Amplification of myc Oncogene in Osteogenic Sarcoma, International Symposium on Limb Salvage Singapore (1993)

    Invited Presentation, Amplification of myc Oncogene in Osteogenic Sarcoma, International Symposium on Limb Salvage

Selected Publications

See list of PubMed publications

Edit this profile