Research Departments & Organizations
Cell Biology; Cells; Developmental Biology; Education, Medical; Endocrine System Diseases; Genetics; Intercellular Signaling Peptides and Proteins; Molecular Biology; Neurodegenerative Diseases; Proteolysis; Serpins; Tissues
My past research focused on cellular and developmental pathways regulated by proteolysis, specifically in embryonic patterning and innate immunity.
Specialized Terms: Proteolysis; Serpins; Intercellular signaling; Morphogenesis; Disease modeling; Drosophila molecular genetics
Extensive Research DescriptionMy laboratory’s original interest was in the molecular mechanism used to establish the dorsoventral axis of the Drosophila embryo. We sought to understand how a protease cascade that triggers dorsoventral patterning is only activated on the prospective ventral side of the embryo. Among our findings, we identified a serpin (serine protease inhibitor) that plays an essential role in ventrally restricting the protease cascade. We then studied proteases and serpins functioning in Drosophila innate immunity as part of a broader interest in biological processes regulated by proteolysis.
A serpin that regulates immune melanization in the respiratory system of Drosophila.
Tang H, Kambris Z, Lemaitre B, Hashimoto C. A serpin that regulates immune melanization in the respiratory system of Drosophila. Developmental Cell 2008, 15:617-26. 2008
Two proteases defining a melanization cascade in the immune system of Drosophila.
Tang H, Kambris Z, Lemaitre B, Hashimoto C. Two proteases defining a melanization cascade in the immune system of Drosophila. The Journal Of Biological Chemistry 2006, 281:28097-104. 2006
The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin.
Richer MJ, Keays CA, Waterhouse J, Minhas J, Hashimoto C, Jean F. The Spn4 gene of Drosophila encodes a potent furin-directed secretory pathway serpin. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101:10560-5. 2004
Spatial regulation of developmental signaling by a serpin.
Hashimoto C, Kim DR, Weiss LA, Miller JW, Morisato D. Spatial regulation of developmental signaling by a serpin. Developmental Cell 2003, 5:945-50. 2003