Carl Hashimoto, PhD

Professor Emeritus of Cell Biology

Research Departments & Organizations

Cell Biology: Developmental Cell Biology and Genetics

Office of Cooperative Research

Research Interests

Cell Biology; Cells; Developmental Biology; Education, Medical; Endocrine System Diseases; Genetics; Intercellular Signaling Peptides and Proteins; Molecular Biology; Neurodegenerative Diseases; Proteolysis; Serpins; Tissues

Research Summary

My past research focused on cellular and developmental pathways regulated by proteolysis, specifically in embryonic patterning and innate immunity.

Specialized Terms: Proteolysis; Serpins; Intercellular signaling; Morphogenesis; Disease modeling; Drosophila molecular genetics

Extensive Research Description

My laboratory’s original interest was in the molecular mechanism used to establish the dorsoventral axis of the Drosophila embryo. We sought to understand how a protease cascade that triggers dorsoventral patterning is only activated on the prospective ventral side of the embryo. Among our findings, we identified a serpin (serine protease inhibitor) that plays an essential role in ventrally restricting the protease cascade. We then studied proteases and serpins functioning in Drosophila innate immunity as part of a broader interest in biological processes regulated by proteolysis.

Selected Publications

See list of PubMed publications

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