Research Departments & Organizations
Biomedical Engineering; Blood; Blood Cells; Bone Marrow Cells; Curriculum; Diagnostic Techniques and Procedures; Disease Management; Education, Professional; Ethics; Hematology; Hematopoietic System; Hemic and Lymphatic Diseases; Immune System; Laboratories; Lymphoid Tissue; Medical Laboratory Science; Point-of-Care Systems; Practice Patterns, Physicians'; Religion and Medicine; Religion and Science; Stem Cells; Students; Students, Medical; Teaching
Dr. Smith's research laboratory primarily investigates the inflammation-coagulation interface, especially at the cellular level, i.e., the interaction of leukocytes and platelets, but also at the level of soluble mediators such as the complement system. A major interest is in relating basic biological events to human disease, for example, studying the mechanisms and consequences of platelet, leukocyte and complement activation during cardiac surgery, as a consequence of transfusion, in the pathophysiology of tumor metastasis, and in primary hematologic disorders. Because of the importance of inflammation-coagulation in the success or failure of clinically utilized biomechanical devices, the laboratory is also engaged in aspects of biomedical engineering.
In addition to these areas, Dr. Smith is involved in clinically oriented research designed to improve hematologic and immunologic diagnostics and ''personalized'' cell therapy, has published in the area of bioethics, and is engaged in educational methodology research to improve medical student education in Laboratory Medicine.
Specialized Terms: Inflammation-Coagulation Interface; Hematology; Bioethics; Biomedical Engineering; Laboratory Medicine Education; Therapeutic Pathology
Laboratory Medicine Education at U.S. Medical Schools: A 2014 Status Report.
Smith BR, Kamoun M, Hickner J. Laboratory Medicine Education at U.S. Medical Schools: A 2014 Status Report. Academic Medicine : Journal Of The Association Of American Medical Colleges 2016, 91:107-12. 2016
Biosimilar biologics: never identical but close enough.
Abi-Raad R, Smith BR. Biosimilar biologics: never identical but close enough. Transfusion 2015, 55:229-31. 2015
Pathology resident and fellow education in a time of disruptive technologies.
Ziai JM, Smith BR. Pathology resident and fellow education in a time of disruptive technologies. Clinics In Laboratory Medicine 2012, 32:623-38. 2012
Educating medical students in laboratory medicine: a proposed curriculum.
Smith BR, Aguero-Rosenfeld M, Anastasi J, Baron B, Berg A, Bock JL, Campbell S, Crookston KP, Fitzgerald R, Fung M, Haspel R, Howe JG, Jhang J, Kamoun M, Koethe S, Krasowski MD, Landry ML, Marques MB, Rinder HM, Roberts W, Schreiber WE, Spitalnik SL, Tormey CA, Wolf P, Wu YY. Educating medical students in laboratory medicine: a proposed curriculum. American Journal Of Clinical Pathology 2010, 133:533-42. 2010