Brian B. Koo, MD

Associate Professor; Director, Sleep Medicine Program at Connecticut Veterans Affairs Healthcare System; Director, Yale Center for Restless Legs Syndrome

Research Departments & Organizations


Center for Neuroepidemiology and Clinical Neurological Research

Pulmonary, Critical Care & Sleep Medicine

Research Interests

Neurology; Restless Legs Syndrome; Sleep; Sleep Apnea, Obstructive; Stroke; Veterans

Research Summary

My main research interests lie in the intersection between neurology and sleep medicine. My current area of focus is on the restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS) and their association with cardiovascular disease. We have compiled epidemiologic evidence that PLMS is associated with the development of cardiovascular disease such as myocardial infarction, peripheral vascular disease and stroke. We are learning from additional studies that hypertension may play a role in this association. I am currently interested in taking a closer look at the sleep physiology in individuals with RLS and PLMS, inspecting specific time domain elements of these limb movements as well as heart rate and breathing. In addition to this vein of research, I have completed work on an animal model of RLS and am currently investigating the human genetics related to this troubling disorder.

Specialized Terms: Restless Legs Syndrome; Periodic Limb Movements During Sleep; Obstructive Sleep Apnea and Stroke

Clinical Trials

Conditions Study Title
Diseases of the Nervous System, Pregnancy, Childbirth and the Puerperium Hypothyroidism and Restless Legs Syndrome in Pregnancy
Diseases of the Endocrine System Investigating the Role of the Polyol Pathway in the Central Nervous System

Selected Publications

See list of PubMed publications

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