Bonnie Gould Rothberg, MD, PhD, MPH

Staff Affiliate - YNHH

Research Departments & Organizations

Obesity Research Working Group

Subset Medical Oncology Faculty

Research Interests

Biomarkers, Pharmacological; Chronic Disease; Epidemiology; Genetics; Genomics; Lung Neoplasms; Medical Oncology; Melanoma; Pancreatic Neoplasms; Pathology; Tuberous Sclerosis

Research Summary

The prognosis for certain localized cancers, such as Stages II & IIIA melanoma and early-stage (Stages IA-IIIA) non-small cell lung cancer is uncertain. Following curative-intent resection of the primary tumor, the long-term (5- or 10-year) overall survival for these patients can hover around 50%. At the same time, the morbidities associated with available adjuvant therapies precludes their use in the majority of these patients. Current prognostic models derived from conventional clinicopathologic parameters are insufficient to identify, at the time of diagnosis, the subset of patients at highest risk of recurrence for selective adjuvant therapy administration. The goal of my research program is to develop novel prognostic models for both early-stage non-small cell lung cancer and melanoma. Variables reflecting characteristics of the index tumor (somatic mutations, copy number variation and differential transcript profiling), the patient's germline genetics as well as lifestyle behaviors are all simultaneously considered.

Specialized Terms: Molecular cancer epidemiology; Cancer prognosis; Melanoma; Skin cancer; Lung cancer; Pancreatic Neuroendocrine Tumors (PNETs); Tuberous Sclerosis Complex; Next generation sequencing; Somatic tumor mutations; Germline genetic variation; Immunohistochemistry-based biomarkers; Biospecimens and biobanking; Lifestyle choices associated with cancer outcome

Clinical Trials

Conditions Study Title
Lung Determining Mechanisms of Sensitivity and Resistance to Anti-Cancer Therapy for Advanced Lung Cancer
Lung Personalized Prevention: Smoking Cessation in Patients With a Lung Nodule

Selected Publications

See list of PubMed publications

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