Research Departments & Organizations
Obesity Research Working Group
Subset Medical Oncology Faculty
The prognosis for certain localized cancers, such as Stages II & IIIA melanoma and early-stage (Stages IA-IIIA) non-small cell lung cancer is uncertain. Following curative-intent resection of the primary tumor, the long-term (5- or 10-year) overall survival for these patients can hover around 50%. At the same time, the morbidities associated with available adjuvant therapies precludes their use in the majority of these patients. Current prognostic models derived from conventional clinicopathologic parameters are insufficient to identify, at the time of diagnosis, the subset of patients at highest risk of recurrence for selective adjuvant therapy administration. The goal of my research program is to develop novel prognostic models for both early-stage non-small cell lung cancer and melanoma. Variables reflecting characteristics of the index tumor (somatic mutations, copy number variation and differential transcript profiling), the patient's germline genetics as well as lifestyle behaviors are all simultaneously considered.
Specialized Terms: Molecular cancer epidemiology; Cancer prognosis; Melanoma; Skin cancer; Lung cancer; Pancreatic Neuroendocrine Tumors (PNETs); Tuberous Sclerosis Complex; Next generation sequencing; Somatic tumor mutations; Germline genetic variation; Immunohistochemistry-based biomarkers; Biospecimens and biobanking; Lifestyle choices associated with cancer outcome
|Lung||Determining Mechanisms of Sensitivity and Resistance to Anti-Cancer Therapy for Advanced Lung Cancer|
|Lung||Personalized Prevention: Smoking Cessation in Patients With a Lung Nodule|
Survivorship care for older adults with cancer: the role of primary care physicians and the utility of care plans as a communication tool
In: Handbook of Geriatric Oncology. Kroc-Grodzicki M and Tew W eds. 2017. 2017
Massively parallel ("next-generation") DNA sequencing.
Gould Rothberg BE, Rothberg JM. Massively parallel ("next-generation") DNA sequencing. Clinical Chemistry 2015, 61:997-8. 2015
Red meat and fruit intake is prognostic among patients with localized cutaneous melanomas more than 1mm thick.
Gould Rothberg BE, Bulloch KJ, Fine JA, Barnhill RL, Berwick M. Red meat and fruit intake is prognostic among patients with localized cutaneous melanomas more than 1mm thick. Cancer Epidemiology 2014, 38:599-607. 2014
Gestational weight gain and subsequent postpartum weight loss among young, low-income, ethnic minority women.
Gould Rothberg BE, Magriples U, Kershaw TS, Rising SS, Ickovics JR. Gestational weight gain and subsequent postpartum weight loss among young, low-income, ethnic minority women. American Journal Of Obstetrics And Gynecology 2011, 204:52.e1-11. 2011
Tissue biomarkers for prognosis in cutaneous melanoma: a systematic review and meta-analysis.
Gould Rothberg BE, Bracken MB, Rimm DL. Tissue biomarkers for prognosis in cutaneous melanoma: a systematic review and meta-analysis. Journal Of The National Cancer Institute 2009, 101:452-74. 2009
Melanoma prognostic model using tissue microarrays and genetic algorithms.
Gould Rothberg BE, Berger AJ, Molinaro AM, Subtil A, Krauthammer MO, Camp RL, Bradley WR, Ariyan S, Kluger HM, Rimm DL. Melanoma prognostic model using tissue microarrays and genetic algorithms. Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology 2009, 27:5772-80. 2009